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Original articles
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M. Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami.
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Cell Rep., 42, 111940 (2023).
Original articles
Takuro Miyazaki, Yoshitaka Taketomi, Takayoshi Higashi, Hirokazu Ohtaki, Takashi Takaki, Koji Ohnishi, Masahiro Hosonuma, Nozomu Kono, Risako Akasu, Shogo Haraguchi, Joo-Ri Kim-Kaneyama, Kinya Otsu, Hiroyuki Arai, Makoto Murakami, Akira Miyazaki.
Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking.
Arterioscler Thromb Vasc Biol., 43, e66-e82 (2022).
Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Keisuke Toda, Saya Maruoka, Yuki Nagasaki, Yoshiko Mori, Risa Sawazumi, Kensuke Okamoto, Keita Kanzaki, Hideyuki Ito, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice.
Free Radic. Biol. Med., 193, 1-8 (2022).
Yuki Nagasaki, Erika Kawai, Saya Maruoka, Miho Osumi, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Yuka Okazaki, Yoshimi Miki, Yoshitaka Taketomi, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects.
Biochem. Biophys. Res. Commun., 630, 84-91 (2022).
S M Khaledur Rahman, Zahir Hussain, Katsuya Morito, Naoko Takahashi, Mohammad Mamun Sikder, Tamotsu Tanaka, Ken-Ichi Ohta, Masaki Ueno, Hiroo Takahashi, Tohru Yamamoto, Makoto Murakami, Toru Uyama, Natsuo Ueda.
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia.
Biochem. Biophys. Acta. Mol. Cell Biol. Lipids., 1867, 159222 (2022).
Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki.
Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.
Sci. Rep., 12, 7312 (2022).
Luyiyun Liang*, Rina Takamiya*, Yoshimi Miki, Kanako Heike, Yoshitaka Taketomi, Nao Sugimoto, Midori Yamaguchi, Hiroshi Shitara, Yasumasa Nishito, Tetsuyuki Kobayashi, Tetsuya Hirabayashi, Makoto Murakami. *Equally contributed.
Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.
FASEB J., 36, e22301(2022).
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E. Ortiz, Nicholas J. Schnicker, Andrew Thurman, Alejandro A. Pezzulo, Peter J. Szachowicz, Pengfei Li, Ruangang Pan, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, Sonia Zuniga, Isabel Sola, Luis Enjuanes, David K. Meyerholz, Kristen Fortney, Paul B. McCray Jr & Stanley Perlman.
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Nature, 605, 146–151 (2022).
Kai Kudo, Yoshimi Miki, Joaquim Carreras, Shunya Nakayama, Yasushi Nakamoto, Masatoshi Ito, Etsuko Nagashima, Kei Yamamoto, Hiroshi Higuchi, Shin-Ya Morita, Asuka Inoue, Junken Aoki, Kiyoshi Ando, Naoya Nakamura, Makoto Murakami, Ai Kotani.
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma.
Cell Metab., 34, 615-633.e8 (2022).
Etienne Doré, Charles Joly-Beauparlant, Satoshi Morozumi, Alban Mathieu, Tania Lévesque, Isabelle Allaeys, Anne-Claire Duchez, Nathalie Cloutier, Mickaël Leclercq, Antoine Bodein, Christine Payré, Cyril Martin, Agnes Petit-Paitel, Michael H Gelb, Manu Rangachari, Makoto Murakami, Laetitia Davidovic, Nicolas Flamand, Makoto Arita, Gérard Lambeau, Arnaud Droit, Eric Boilard.
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.
JCI Insight, 7, e152638 (2022).
Yoshimi Miki, Yoshitaka Taketomi, Yuh Kidoguchi, Kei Yamamoto, Kazuaki Muramatsu, Yasumasa Nishito, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Tomoyoshi Soga, Eric Boilard, Siddabasave Gowda B. Gowda, Kazutaka Ikeda, Makoto Arita, Makoto Murakami.
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.
JCI Insight, 7: e152611 (2022).
Review article
Makoto Murakami, Rina Takamiya, Yoshimi Miki, Nao Sugimoto, Yuki Nagasaki, Toshiko Suzuki-Yamamoto, YoshitakaTaketomi.
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation.
Biochem. Pharmacol., 203, 115176 (2022).
Yoshitaka Taketomi, Makoto Murakami.
Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology.
Front. Immunol., 13, 923265 (2022).
Yoshitaka Taketomi, Yoshimi Miki, Makoto Murakami.
Old but new: Group IIA phospholipase A2 as a modulator of gut microbiota.
Metabolites, 12, 352 (2022).
Original articles
Yoshitaka Taketomi, Yuki Endo, Takayoshi Higashi, Remi Murase, Tomio Ono, Choji Taya, Tetsuyuki Kobayashi, Makoto Murakami.
Mast cell-specific deletion of group III secreted phospholipase A2 impairs mast cell maturation and functions.
Cells, 10: 1691 (2021).
Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael H. Gelb, Makoto Murakami, Stanley Perlman.
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
J. Clin. Invest., 131: e147201 (2021).
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Nicholas J Schnicker, Alejandro A Pezzulo, Peter J Szachowicz, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, David K Meyerholz, Kristen Fortney, Paul B McCray, Stanley Perlman.
Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19.
bioRxiv., Preprint (doi: 10.1101/2021.04.20.440676) (2021).
Daisuke Fujioka, Yosuke Watanabe, Takamitsu Nakamura, Takashi Yokoyama, Keiji Miyazawa, Makoto Murakami, Kiyotaka Kugiyama.
Group V secretory phospholipase A2 regulates endocytosis of acetylated LDL by transcriptional activation of PGK1 in RAW264.7 macrophage cell line.
J. Atheroscler. Thromb., Online ahead of print (2021).
Review article
Jiro Kitaura, Makoto Murakami.
Positive and negative roles of lipids in mast cells and allergic responses.
Curr. Opin. Immunol., 72: 186-195 (2021).
Original articles
Morishita, M., Kanda, Y., Kaizuka T., Chino, H., Nakao, K., Miki, Y., Taketomi, Y., Jun-Lin Guan, Murakami, M., Aiba, A., Mizushima, N.
Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder.
Cell Reports, 33, 108477, 2020.
Inazumi, T., Yamada, K., Shirata, N., Sato, H., Taketomi, Y., Morita, K., Hohjoh, H., Tsuchiya, S., Oniki, K., Watanabe, T., Sasaki, Y., Oike, Y., Ogata, Y., Saruwatari, J., Murakami, M., Sugimoto, Y.
Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance.
Cell Reports, 33, 108265, 2020
Watanabe, K., Taketomi, Y., Miki, Y., Kugiyama, K., Murakami, M.
Endothelial group V secreted phospholipase A2 plays a protective role against aortic dissection.
J. Biol. Chem., 295, 10092-10111, 2020
Sato, H., Taketomi, Y., Miki, Y., Murase, R., Yamamoto, K., Murakami, M.
Secreted phospholipase PLA2G2D contributes to metabolic health by mobilizing omega-3 polyunsaturated fatty acids in white adipose tissue.
Cell Rep., 31, 107579, 2020
Sano, Y.*, Toyoshima, S.*, Miki, Y.*, Taketomi, Y., Ito, M., Lee, H., Saito, S., Murakami, M., Okayama, Y. *Contributed eaqually.
Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis.
Asia Pac. Allergy, 10, e21, 2020
Toda, K., Tsukayama, I., Nagasaki, Y., Yuka, K., Tamenobu, A., Ganeko, N., Ito, H., Kawakami, Y., Takahashi, Y., Miki, Y., Yamamoto, K., Murakami, M., Suzuki-Yamamoto, T.
Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation.
Arch. Biochem. Biophys., 689, 2020
Review article
Murakami, M., Sato, H., Taketomi Y.
Updating Phospholipase A2 Biology.
Biomolecules, 10, 1457, 2020
Original articles
Mori, A., Hatano, T., Inoshita, T., Shiba-Fukushima, K., Koinuma, T., Meng, H., Kubo, S.I., Spratt, S., Cui, C., Yamashita, C., Miki, Y., Yamamoto, K., Hirabayashi, T., Murakami, M., Takahashi, Y., Shindou, H., Nonaka, T., Hasegawa, M., Okuzumi, A., Imai, Y., Hattori, N.
Parkinson’s disease-assocaitaed iPLA2-VIA/PLA2G6 regulates neuronal functions and a-synuclein stability through membrane remodeling.
Proc. Natl. Acad. Sci. USA., 116, 20689-20699, 2019
Jin, F., Li, X., Deng, Y., Timilshina, M., Huang, B., Kim, D.Y., Chang, J.H., Ichinose, H., Baek, S.H., Murakami, M., Lee, Y.J., Chang, H.W.
The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Allergy, 74, 1145-1156, 2019
Review articles
Murakami, M.
Novel functions of phospholipase A2s: Overview.
Biochim. Biophys. Acta., 1864, 763-765, 2019
Murakami, M., Miki, Y., Sato, H., Murase R, Taketomi, Y., Yamamoto K.
Group IID, IIE, IIF and III secreted phospholipase A2s.
Biochim. Biophys. Acta., 1864, 803-818, 2019
Hirabayashi, T., Murakami, M., Kihara A.
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function.
Biochim. Biophys. Acta., 1864, 869-879, 2019
Original articles
Murakami, M., Yamamoto, K., Taketomi, Y.
Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics.
Inflamm. Regen., 38, 31, 2018
Li, X., Park, S.J., Jin, F., Deng, Y., Yang, J.H., Chang, J.H., Kim, D.Y., Kim, J.A., Lee, Y.J., Murakami, M., Son, K.H., Chang, H.W.
Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.
Biochem. Pharmacol., 152, 362-372, 2018
Tsukayama, I., Toda, K., Takeda, Y., Mega, T., Tanaka, M., Kawakami, Y., Takahashi, Y., Kimoto, M., Yamamoto, K., Miki, Y., Murakami, M., and Suzuki-Yamamoto, T.
Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway.
J. Clin. Biochem. Nutr., 62, 139-147, 2018
Original articles
Shimanaka, Y. & Kono, N., Taketomi, Y., Arita, M., Okayama, Y., Tanaka, Y., Nishito, Y., Mochizuki, T., Kusuhara, H., Adibekian, A., Cravatt, B.F., and Murakami, M. & Arai, H.
ω3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Nat. Med., 23, 1287-1297, 2017
Murase, R., Taketomi, Y., Miki, Y., Nishito, Y., Saito, M., Fukami, K., Yamamoto, K., and Murakami, M.
Group III phospholipase A2 promotes colitis and colorectal cancer.
Sci. Rep., 7, 12261, 2017
Li, X., Lee, Y. J., Jin, F., Park,Y. N., Deng, Y., Kang, Y., Yang, J. H., Chang, J. H., Kim, D. Y., Kim, J. A., Chang, Y. C., Ko, H. J., Kim, C. H., Murakami, M., and Chang, H. W.
Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Sci. Rep., 7, 6444, 2017
Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, T., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., and Aoki, J.
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
EMBO J., 36, 2146-2160, 2017
Irie, A., Yamamoto, K., Miki, Y., and Murakami, M.
Phosphatidylethanolamine dynamics are required for osteoclast fusion.
Sci. Rep., 7, 46715, 2017
Hirabayashi, T., Anjo, T., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., Muramatsu, K., Fukami, K., Muñoz-Garcia, A., Brash, A.R., Ikeda, K., Arita, M., Akiyama, A., and Murakami, M.
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Nat. Commun., 8, 14609, 2017
Review articles
Murakami, M.
Lipoquality control by phospholipase A2 enzymes.
Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci., 93, 677-702, 2017
Taketomi, Y., Murakami, M.
Immunological regulation by bioactive lipids.
Yakugaku Zasshi, 137, 503-515, 2017
Yamamoto, K., Miki, Y., Sato, H., Murase, R., Taketomi, Y., and Murakami, M.
Methods Enzymol., 583, 101-117, 2017
Original articles
Hata, S., Kitamura, F., Yamaguchi, M., Shitara, H., Murakami, M., and Sorimachi, H.
A gastrointestinal calpain complex, G-calpain, is a heterodimer of CAPN8 and CAPN9 calpain isoforms, which play catalytic and regulatory roles, respectively.
J. Biol. Chem., 291, 27313-27322, 2016
Tanigawa, H., Miyata, K., Tian, Z., Kadomatsu, T., Aoi, J., Fukushima, S., Ogata, A., Takeda, N., Zhao, J., Zhu, S., Terada, K., Endo, M., Morinaga, J., Sugizaki, T., Sato, M., Morioka, M., Manabe, I., Mashimo, Y., Hata, A., Taketomi, Y., Yamamoto, K., Murakami, M., Araki, K., Jinnin, M., Ihn, H., and Oike, Y.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci. Rep., 6, 34690, 2016
Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J., Murakami, M., Hoka, S., and Yokomizo, T.
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.
Sci. Rep., 6, 34560, 2016
Peña, L., Meana, C., Astudillo, A.M., Lordén, G., Valdearcos, M., Sato, H., Murakami, M., Balsinde, J., and Balboa, M.A.
Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.
Biochim. Biophys. Acta., 1861(9 Pt A), 1083-1095, 2016.
Yamamoto, K., Miki, Y., Sato, H., Nishito, Y., Gelb, M.H., Taketomi, Y., and Murakami, M.
Expression and function of group IIE phospholipase A2 in mouse skin.
J. Biol. Chem., 291, 15602-15613, 2016
Miki, Y., Kidoguchi, Y., Sato, M., Taketomi, Y., Taya, C., Muramatsu, K., Gelb, M.H., Yamamoto, K., and Murakami, M.
Dual roles of group IID phospholipase A2 in inflammation and cancer.
J. Biol. Chem., 291, 15588-15601, 2016
Murase, R., Sato, H., Yamamoto, K., Ushida, A., Nishito, Y., Ikeda, K., Kobayashi, T., Yamamoto, T., Taketomi, Y., and Murakami, M.
Group X secreted phospholipase A2 releases ω-3 polyunsaturated fatty acids, suppresses colitis and promotes sperm fertility.
J. Biol. Chem., 291, 6895-6911, 2016
Li, X., Kwon, O., Kim, D.Y., Taketomi, Y., Murakami, M., and Chang, H.W.
NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module.
Allergy, 71, 198-209, 2016
Review articles
Murakami, M., Yamamoto, K., Miki, Y., Murase, R., Sato, H., and Taketomi, Y.
The roles of the secreted phospholipase A2 (sPLA2) gene family in immunology.
Adv. Immunol., 132, 91-134, 2016
Murakami, M., Taketomi, Y., and Sato, H.
Metabolic regulation by secreted phospholipase A2.
Inflamm. Regener., 36, 1–7, 2016
Original articles
Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M.
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J. Exp. Med., 212, 1901–1919, 2015
Vijay, R., Hua, X., Meyerholz, D.K., Miki, Y., Yamamoto, K., Gelb, M.H., Murakami, M., and Perlman, S.
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
J. Exp. Med., 212, 1851-1868, 2015
Gijs, H.L., Willemarck, N., Vanderhoydonc, F., Khan, N. A., Dehairs, J., Derua, R., Waelkens, E., Taketomi, Y., Murakami, M., Agostinis, P., Annaert, W., and Swinnen, J.V.
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Mol. Biol. Cell., 26, 2321-2332, 2015
Kazama, S., Kitayama, J., Hiyoshi, M., Taketomi, Y., Murakami, M., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Kawai, K., Hata, K., Yamaguchi, H., Nozawa, H., Ishihara, S, Sunami, E., and Watanabe, T.
Phospholipase A2 group III and group X have opposing associations with prognosis in colorectal cancer.
Anticancer Res., 35, 2983-2990, 2015
Berry, E., Hernandez-Anzaldo, S., Ghomashchi, F., Lehner, R., Murakami, M., Gelb, M.H., Kassiri, Z., Wang, X., and Fernandez-Patron, C.
Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
J. Am. Heart Assoc., 4, pii: e001868, 2015
Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J. R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
Circ. Res., 116, 1170-1181, 2015
Review articles
Yokomzo, T., and Murakami, M.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 2015 (Editors)
Murakami, M., and Taketomi, Y.
Phospholipase A2.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 23-42, 2015
Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
A new era of secreted phospholipase A2.
J. Lipid Res., 56, 1248-1261, 2015
Murakami, M., and Taketomi, Y.
Secreted phospholipase A2s and mast cells.
Allergology Int., 64, 4-10, 2015
Original articles
Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M.H., and Murakami, M.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Cell Metab., 20, 119-132, 2014
Yoda, E., Rai, K., Ogawa, M., Takakura, Y., Kuwata, H., Suzuki, H., Nakatani, Y., Murakami, M., and Hara, S.
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
PLoS One., 9, e109409, 2014
Hwang, S.K., Lu, Y., Li, X., Kim, Y.D., Cho, Y.S., Jahng, Y., Son, J.K., Lee, Y.J., Kang, W., Taketomi, Y., Murakami, M., Moon, T.C., and Chang, H.W.
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
J. Allergy Clin. Immunol., 134, 714-721. e7, 2014
Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
J. Immunol., 192, 1130-1137, 2014
Mishina, H., Tamaru, S., Watanabe, K., Watanabe, Y., Fujioka, D., Takahashi, S., Suzuki, K., Nakamura, T., Obata, J., Kawabata, K., Yokota, Y., Inoue, O., Murakami, M., Hanasaki, K., and Kugiyama, K.
Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
Circ. Res., 114, 493-504, 2014
Udagawa, O., Ito, C., Ogonuki, N., Sato, H., Lee, S., Tripvanuntakul, P., Ichi, I., Uchida, Y., Nishimura, T., Murakami, M., Ogura, A., Inoue, T., Toshimori, K., and Arai, H.
Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
Genes Cells, 19, 13–27, 2014
Review article
Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.
Biochimie., 107, 105-113, 2014
Original articles
Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.H., and Murakami, M.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
J. Exp. Med., 210, 1217-1234, 2013
Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nat. Immunol., 14, 554-563, 2013
Tamaru, S, Mishina, H, Watanabe, Y, Watanabe, K, Fujioka, D, Takahashi S, Suzuki, K, Nakamura, T, Obata, JE, Kawabata, K, Yokota, Y, Murakami, M,, Hanasaki, K, and Kugiyama, K.
Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.
J. Immunol., 191,1021-1028, 2013
Morita, Y., Sakaguchi, T., Ikegami, K., Goto-Inoue, N., Hayasaka, T. Hang, V.T., Tanaka, H., Harada, T., Shibasaki, Y., Suzuki, A., Inaba, K., Murakami, M., Setou, M., and Konno, H.
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
J. Hepatol., 59, 292-299, 2013
Miki, T., Kaneda, M., Iida, K., Hasegawa, G., Murakami, M., Yamamoto, N., Asou, H., and Kasahara K.
An anti-sulfatide antibody O4 immunoprecipitates sulfatide rafts including Fyn, Lyn and the G protein α subunit in rat primary immature oligodendrocytes.
Glycoconj. J., 30, 819-823, 2013
Lu, Y., Piao, D., Zhang, H., Li, X., Chao, G.H., Park, S.J., Chang, Y.C., Kim, C.H., Murakami, M., Jung, S.H., Choi, J.H., Son, J.K., and Chang, H.W.
Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcεRI-mediated mast cells.
Food Chem. Toxicol., 59C, 696-702, 2013
Lu, Y., Na, M.K., Suh, S.J., Li, X., Kim, G.J., Chao, G.H., Jeong, Y.T., Kim, D.S., Chang, Y.C., Murakami, M., Kang, W., Kim, C.H., and Chang, H.W.
Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2- dependent prostaglandin D2 generation in mast cells and anaphylaxis in mice.
Food Chem. Toxicol., 57, 307-313, 2013
Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., and Yanoshita, R.
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
Biol. Pharm. Bull., 36, 66-75, 2013.
Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanabe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadawaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, M. J., Arita, M., and Imai, Y.
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Cell, 153, 112-125, 2013
Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T., Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., and Chang, H.W.
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.
J. Allergy Clin. Immunol., 132, 729-736, 2013
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., and Watanabe, T
The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.
Oncol. Lett., 5, 533-538, 2013
Ait-Oufella, H., Herbin, O., Lahoute, C., Coatrieux, C., Loyer, X., Joffre, J., Laurans, L., Ramkhelawon, B., Blanc-Brude, O., Karabina, S., Girard, C.A., Payré, C., Yamamoto, K., Binder, C. J., Murakami, M., Tedgui, A., Lambeau, G., and Mallat, Z.
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor–null mice
Arterioscler Thromb. Vasc. Biol., 33, 466-473, 2013
Review article
Murakami, M. and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: an update.
Biochimie, 95, 43-50, 2013
Original articles
Nakahigashi, K., Otsuka, A., Doi, H., Hirabayashi, T., Murakami, M., Urade, Y., Tanizaki, H., Egawa, G., Miyachi, Y., and Kabashima, K.
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis.
J. Allergy Clin. Immunol., 129, 536-543, 2012
Sasaki, Y., Kamei, D., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Murakami, M., and Hara, S.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Oncogene, 31, 2943-2952, 2012
Lu,Y., Suh, S.J., Li, X., Hwang, S.L., Li, Y., Hwangbo, K., Park, S.J., Murakami, M., Lee, S.H., Jahng, Y., Son, J.K., Kim, C.H., and Chang, H.W.
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Food Chem. Toxicol., 50, 4382-4388, 2012
Lu, Y., Suh, S.J., Li, X., Liang, J.L., Chi, M., Hwangbo, K., Kwon, O., Chung, T.W., Kwak, C.H., Kwon, K.M., Murakami, M., Jahng, Y., Kim, C.H., Son, J.K., and Chang, H.W.
Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-kB and activator protein-1 activation in mouse bone marrow-derived mast cells.
Biol. Pharm. Bull., 35, 938-945, 2012
Review article
Murakami, M. and Taketomi, Y.
Unraveling the secrets of secreated phopholipase A2.
Trends Cell Mol. Biol., 7, 57-71, 2012
Original articles
Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., and Murakami, M.
Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts.
J. Biol. Chem., 286, 37249-37263, 2011
Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
J. Biol. Chem., 286, 11616-11631, 2011
Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
J. Biol. Chem., 286, 11632-11648, 2011
Lu , Y., Yang , J.H., Li , X., Hwangbo, K., Hwang , S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., and Chang, H.W.
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Biochem. Pharmacol., 82, 1700-1708, 2011
Miyazaki, T., Taketomi, Y., Takimoto, M.,Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice.
Circulation, 124, 2522-2532, 2011
Review articles
Murakami, M., Taketomi, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Secreted phospholipase A2 revisited.
J. Biochem., 150, 233-255, 2011
Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Resent progress in phospholipase A2 research: From cells to animals to humans.
Prog. Lipid Res., 50, 152-192, 2011
Murakami, M.
Lipid mediators in life science.
Exp. Anim., 60, 7-20, 2011
Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
Integrated lipidomics in the secreted phospholipase A2 biology.
Int. J. Mol. Sci., 12, 1474-1495, 2011
Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., and Murakami, M.
Secreted phospholipase A2, Lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics.
Anal. Bioanal. Chem.，400, 1829-1842, 2011
Taketomi, Y. and Murakami, M.
Phospholipase A2 as a potential target of airway diseases.
Obstructive Airway Diseases: Role of Lipid Mediators, 39-67, 2011
Original articles
Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
J. Clin. Invest., 120, 1400-1414, 2010
Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
J. Clin. Invest., 120, 1415-1428, 2010
Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., Kudo, I., and Hara S.
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca2+-indpendent phospholipase A2 (iPLA2 gamma) deficient mice.
J. Lipid Res., 51, 3003-3015, 2010
Review articles
Murakami, M., Taketomi, Y., Girard, C., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.
Biochimie, 92, 561-582, 2010
Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., and Murakami, M.
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
Biochimie, 92, 651-659, 2010
Original articles
Kamei, D., Murakami, M., Sasaki, Y., Nakatani, Y., Majima, M., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Hara, S., and Kudo, I.
Microsomal prostaglandin E synthase-1in both cancercells and hosts contributes to tumor growth, invasion and metastasis.
Biochem. J., 425, 361-371, 2009
Ishikawa, Y., Kimura-Matsumoto, M., Murakami, M., Yamamoto, K., Akasaka, Y., Uzuki, M., Yuri, Y., Inomata, N., Yokoo, T. and Ishii, T.
Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis.
J. Atheroscler. Throm., 16, 829-839, 2009
Sato, H., Taketomi, Y., Isogai, Y., Masuda, S., Kobayashi, T., Yamamoto, K., and Murakami, M.
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Biochem. J., 421, 17-27, 2009
Nakamura, Y., Kambe, N., Saito, M., Mishikomori, R., Kim, Y.-G., Murakami, M., Nunez, G., and Matsue, H.
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
J. Exp. Med., 206, 1037-1046, 2009
Review article
Arata, S., Hosono, T., Taketomi, Y., Kageyama, H., Nakamachi, T., and Shioda, S.
Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1R) transgenic mice.
Transmitters and Modulators in Health and Disease, Springer-Verlag, 199-205, 2009
Original articles
Sato, H., Kato, R., Isogai, Y., Saka, G., Ohtsuki, M., Taketomi, Y., Yamamoto, K., Tsutsumi, K., Yamada, J., Masuda, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Ikeda, K., Taguchi, R., Hatakeyama, S., Hara, S., Kudo, I., Itabe, H., and Murakami, M.
Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
J. Biol. Chem., 283, 33483-33497, 2008
Ueno, N., Taketomi, Y., Koga, K., Atsumi, Y., Kikuchi-Yanoshita, R., Kudo, I., and Murakami, M.
A negative regulator of delayed prostaglandin D2 production in mouse mast cells.
Biochim. Biophys. Acta, 1781, 415-421, 2008
Masuda, S., Yamamoto, K., Hirabayashi, T., Ishikawa, Y., Ishii, T., Kudo, I., and Murakami, M.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Biochem. J., 409, 429-438, 2008
Yamakawa, K., Kamekura, S., Kawamura, N., Saegusa, M., Kamei, D., Murakami, M., Kudo, I., Uematsu, S., Akira, S., Chung, U.I., Nakamura, K., and Kawaguchi, H.
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis Rheum., 58, 172-183, 2008
Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takamatsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, S.
Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells.
FEBS Lett., 582, 1444-1450, 2008
Kimura-Matsumoto, M., Ishikawa, Y., Komiyama, K., Tsuruta, T., Murakami, M., Masuda, S., Akasaka, Y., Ito, K., Ishiguro, S., Morita, H., Sato, S., and Ishii, T.
Expression of secretory phospholipase A2s in human atherosclerosis development.
Atherosclerosis, 196, 81-91, 2008
Shimizu, M., Nakamura, H., Hirabayashi, T., Suganami, A., Tamura, Y., and Murayama, T.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2 alpha (cPLA2 alpha) by calmodulin-dependent protein kinase: Possible interaction with catalytic domain A of cPLA2 alpha.
Cell Signal., 20, 815-824, 2008
Shimizu, M., Matsumoto, Y., Kurosawa, T., Azuma, C., Enomoto, M., Nakamura, H., Hirabayahsi, T., Kaneko, M., Okuma, Y., and Murayama, T.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase cPLA2 alpha-independent pathway.
Biochem. Pharmacol., 75, 1358-1369, 2008
Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T.
Cytosolic PLA2 alpha activation in purkinje neurons and its role in AMPA-receptor trafficking..
J. Cell Sci., 121, 3015-1024, 2008
Nabemoto, M., Mashimo, M., Someya, A., Nakamura, H., Hirabayashi, T., Fujino, H., Kaneko, M., Okuma, Y., Saito, T., Yamaguchi, N., and Murayama, T.
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A2 alpha .
Eur. J. Parmacol., 590, 1-11, 2008
Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., and Hanada, K.
RalA functions as an indispensable signal mediator for nutrient sensing system.
J. Biol. Chem., 283, 35053-35059, 2008
Original articles
Kuwata, H., Fujimoto, C., Yoda, E., Nakatani, Y., Hara, S., Murakami, M., and Kudo, I.
A novel role of group VIB calcium-independent phospholipase A2 (iPLA2 gamma) in the inducible expression of group IIA secretory phospholipase A2 in rat fibroblastic cells.
J. Biol. Chem., 282, 20124-20132, 2007
Taketomi, Y., Sunaga, K., Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T.C., Chang, H.W., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I.
Impaired mast cell maturation and degradation and attenuated allergic responses in Ndrg1-deficient mice.
J. Immunol., 178, 7042-7053, 2007
Miki, Y., Mukae, S., Murakami, M., Ishikawa, Y., Ishii, T., Ohki, H., Matsumoto, M., and Komiyama, K.
Butylate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2.
Anti-Cancer Res., 27, 1493-1502, 2007
Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Vanadate-induced activation of cytosolic phospholipase A2 alpha in L929 cells; roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Biochem. Pharm., 73, 854-862, 2007
Original articles
Ohtsuki, M., Taketomi, Y., Arata, S., Masuda, S., Ishikawa, Y., Ishii, T., Takanezawa, Y., Aoki, J., Arai, H., Yamamoto, K., Kudo, I., and Murakami. M.
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
J. Biol. Chem., 281, 36420-36433, 2006
Wijewickrama, G.T., Albanese, A., Kim, Y.J., Oh, Y.S., Murray, P.S., Takayanagi, R., Tobe, T., Masuda, S., Murakami, M., Kudo, I., Ucker, D. S., Murray, D., and Cho, W.
Unique membrane interaction mode of group IIF phospholipase A2.
J. Biol. Chem., 281, 32741-32754, 2006
Mitsuishi, M., Masuda, S., Kudo, I., and Murakami, M.
Group V and X secretory phospholipase A2s prevent adenovirus infection into mammalian cells.
Biochem. J., 393, 97-106, 2006
Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, K., and Maehama, T.
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Mol. Biol. Cell., 17, 4888-4895, 2006
Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., and Murayama, T.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2 alpha.
Eur. J. Pharmacol., 546, 1–10, 2006
Akiyama, N., Nabemoto, M., Hatori, Y., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Up-reguration of cytosolic phospholipase A2 alpha expression by N,N-dimethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.
Toxicol. Appl. Pharmacol., 215, 218–227, 2006
Nakamura, H., Hirabayashi, T., Shimizu, M., and Murayama, T.
Ceramide-1-phosphate activates cytosolic phospholipase A2 alpha directly and by PKC pathway.
Biochem. Pharmacol., 71, 850–857, 2006
Review article
Murakami, M. and Kudo, I.
Prostaglandin E syhthase: a novel drug target for inflammation and cancer.
Curr. Pharm. Des., 12, 943-954, 2006
Original articles
Kubota, K., Kubota, K., Kamei, D., Murakami, M., Kudo, I., Aso, I., and Morita, I.
Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.
J. Endocrinol., 187, 339-345, 2005
Ishikawa, Y., Komiyama, I., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima, Y., Kimura, M., Fujimoto, A., Kudo, I., and Ishii, T.
Expression of type V secretory phospholipase A2 in myocardial remodeling after infarction.
Histopathology, 47, 257-267, 2005
Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., and Kudo, I.
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.
Biochem. J., 387, 27-38, 2005
Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.
Biochim. Biophys. Acta, 1736, 200-210, 2005
Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells.
FEBS J., 272, 655-672, 2005
Kuwata, H., Nonaka, T., Murakami, M., and Kudo, I.
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
J. Biol. Chem., 280, 25830-25839, 2005
Murakami, M., Masuda, S., Shimbara, S., Ishikawa, Y., Ishii, T., and Kudo, I.
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A2.
J. Biol. Chem., 280, 24987-24998, 2005
Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., and Kudo, I.
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
J. Biol. Chem., 280, 23203-23214, 2005
Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., and Kudo, I.
Group VIB Ca2+-independent phospholipase A2 (iPLA2 gamma) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s.
J. Biol. Chem., 280, 14028-14041, 2005
Okahara, F., Itoh, K., Ebihara, M., Kobayashi, M., Maruyama, H., Kanaho, Y., and Maehama, T.
Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein.
Anal. Biochem., 336, 138-140, 2005
Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, M. A., Tanaka, K., Penninger, J. M., Yonekawa, H., Suzuki, A., and Kanaho, Y.
Regulation of anaphylactic response by phosphatidylinositol phosphate kinase type Ia.
J. Exp. Med., 201，859-870，2005
Miyazaki, H., Yamazaki, M., Watanabe, H., Maehama, T., Yokozeki, T., and Kanaho, Y.
The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.
FEBS Lett., 579, 6834-6838, 2005
Review articles
Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., and Murakami, M.
Coupling between cyclooxygenasesand terminal prostanoid synthases.
Biochem. Biophys. Res. Commun., 338, 70-76, 2005
Kudo, I. and Murakami, M.
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis..
J. Biochem. Mol. Biol., 38, 633-638, 2005