Publications of LMMHS

 

Last updated 2019-04-24

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2018  

Original articles

Li, X., Park, S.J., Jin, F., Deng, Y., Yang, J.H., Chang, J.H., Kim, D.Y., Kim, J.A., Lee, Y.J., Murakami, M., Son, K.H., Chang, H.W.
Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.
Biochem. Pharmacol., 152, 362-372, 2018

Tsukayama, I., Toda, K., Takeda, Y., Mega, T., Tanaka, M., Kawakami, Y., Takahashi, Y., Kimoto, M., Yamamoto, K., Miki, Y., Murakami, M., and Suzuki-Yamamoto, T.
Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway.
J. Clin. Biochem. Nutr., 62, 139-147, 2018


Review articles

Hirabayashi, T., Murakami, M., Kihara, A.
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function.
BBA Mol. Cell Biol. Lipids., in press.

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2017  

Original articles

Shimanaka, Y. & Kono, N., Taketomi, Y., Arita, M., Okayama, Y., Tanaka, Y., Nishito, Y., Mochizuki, T., Kusuhara, H., Adibekian, A., Cravatt, B.F., and Murakami, M. & Arai, H.
ω3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Nat. Med., 23, 1287-1297, 2017

Murase, R., Taketomi, Y., Miki, Y., Nishito, Y., Saito, M., Fukami, K., Yamamoto, K., and Murakami, M.
Group III phospholipase A2 promotes colitis and colorectal cancer.
Sci. Rep., 7, 12261, 2017

Li, X., Lee, Y. J., Jin, F., Park,Y. N., Deng, Y., Kang, Y., Yang, J. H., Chang, J. H., Kim, D. Y., Kim, J. A., Chang, Y. C., Ko, H. J., Kim, C. H., Murakami, M., and Chang, H. W.
Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Sci. Rep., 7, 6444, 2017

Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, T., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., and Aoki, J.
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
EMBO J., 36, 2146-2160, 2017

Irie, A., Yamamoto, K., Miki, Y., and Murakami, M.
Phosphatidylethanolamine dynamics are required for osteoclast fusion.
Sci. Rep., 7, 46715, 2017

Hirabayashi, T., Anjo, T., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., Muramatsu, K., Fukami, K., Muñoz-Garcia, A., Brash, A.R., Ikeda, K., Arita, M., Akiyama, A., and Murakami, M.
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Nat. Commun., 8, 14609, 2017


Review articles

Murakami, M.
Lipoquality control by phospholipase A2 enzymes.
Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci., 93, 677-702, 2017

Taketomi, Y., Murakami, M.
Immunological regulation by bioactive lipids.
Yakugaku Zasshi, 137, 503-515, 2017

Yamamoto, K., Miki, Y., Sato, H., Murase, R., Taketomi, Y., and Murakami, M.
Methods Enzymol., 583, 101-117, 2017

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2016  

Original articles

Hata, S., Kitamura, F., Yamaguchi, M., Shitara, H., Murakami, M., and Sorimachi, H.
A gastrointestinal calpain complex, G-calpain, is a heterodimer of CAPN8 and CAPN9 calpain isoforms, which play catalytic and regulatory roles, respectively.
J. Biol. Chem., 291, 27313-27322, 2016

Tanigawa, H., Miyata, K., Tian, Z., Kadomatsu, T., Aoi, J., Fukushima, S., Ogata, A., Takeda, N., Zhao, J., Zhu, S., Terada, K., Endo, M., Morinaga, J., Sugizaki, T., Sato, M., Morioka, M., Manabe, I., Mashimo, Y., Hata, A., Taketomi, Y., Yamamoto, K., Murakami, M., Araki, K., Jinnin, M., Ihn, H., and Oike, Y.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci. Rep., 6, 34690, 2016

Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J., Murakami, M., Hoka, S., and Yokomizo, T.
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.
Sci. Rep., 6, 34560, 2016

Peña, L., Meana, C., Astudillo, A.M., Lordén, G., Valdearcos, M., Sato, H., Murakami, M., Balsinde, J., and Balboa, M.A.
Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.
Biochim. Biophys. Acta., 1861(9 Pt A), 1083-1095, 2016.

Yamamoto, K., Miki, Y., Sato, H., Nishito, Y., Gelb, M.H., Taketomi, Y., and Murakami, M.
Expression and function of group IIE phospholipase A2 in mouse skin.
J. Biol. Chem., 291, 15602-15613, 2016

Miki, Y., Kidoguchi, Y., Sato, M., Taketomi, Y., Taya, C., Muramatsu, K., Gelb, M.H., Yamamoto, K., and Murakami, M.
Dual roles of group IID phospholipase A2 in inflammation and cancer.
J. Biol. Chem., 291, 15588-15601, 2016

Murase, R., Sato, H., Yamamoto, K., Ushida, A., Nishito, Y., Ikeda, K., Kobayashi, T., Yamamoto, T., Taketomi, Y., and Murakami, M.
Group X secreted phospholipase A2 releases ω-3 polyunsaturated fatty acids, suppresses colitis and promotes sperm fertility.
J. Biol. Chem., 291, 6895-6911, 2016

Li, X., Kwon, O., Kim, D.Y., Taketomi, Y., Murakami, M., and Chang, H.W.
NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module.
Allergy, 71, 198-209, 2016


Review articles

Murakami, M., Yamamoto, K., Miki, Y., Murase, R., Sato, H., and Taketomi, Y.
The roles of the secreted phospholipase A2 (sPLA2) gene family in immunology.
Adv. Immunol., 132, 91-134, 2016

Murakami, M., Taketomi, Y., and Sato, H.
Metabolic regulation by secreted phospholipase A2.
Inflamm. Regener., 36, 1–7, 2016

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2015  

Original articles

Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M.
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J. Exp. Med., 212, 1901–1919, 2015

Vijay, R., Hua, X., Meyerholz, D.K., Miki, Y., Yamamoto, K., Gelb, M.H., Murakami, M., and Perlman, S.
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
J. Exp. Med., 212, 1851-1868, 2015

Gijs, H.L., Willemarck, N., Vanderhoydonc, F., Khan, N. A., Dehairs, J., Derua, R., Waelkens, E., Taketomi, Y., Murakami, M., Agostinis, P., Annaert, W., and Swinnen, J.V.
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Mol. Biol. Cell., 26, 2321-2332, 2015

Kazama, S., Kitayama, J., Hiyoshi, M., Taketomi, Y., Murakami, M., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Kawai, K., Hata, K., Yamaguchi, H., Nozawa, H., Ishihara, S, Sunami, E., and Watanabe, T.
Phospholipase A2 group III and group X have opposing associations with prognosis in colorectal cancer.
Anticancer Res., 35, 2983-2990, 2015

Berry, E., Hernandez-Anzaldo, S., Ghomashchi, F., Lehner, R., Murakami, M., Gelb, M.H., Kassiri, Z., Wang, X., and Fernandez-Patron, C.
Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
J. Am. Heart Assoc., 4, pii: e001868, 2015

Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J. R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
Circ. Res., 116, 1170-1181, 2015


Review articles

Yokomzo, T., and Murakami, M.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 2015 (Editors)

Murakami, M., and Taketomi, Y.
Phospholipase A2.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 23-42, 2015

Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
A new era of secreted phospholipase A2.
J. Lipid Res., 56, 1248-1261, 2015

Murakami, M., and Taketomi, Y.
Secreted phospholipase A2s and mast cells.
Allergology Int., 64, 4-10, 2015

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2014  

Original articles

Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M.H., and Murakami, M.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Cell Metab., 20, 119-132, 2014

Yoda, E., Rai, K., Ogawa, M., Takakura, Y., Kuwata, H., Suzuki, H., Nakatani, Y., Murakami, M., and Hara, S.
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
PLoS One., 9, e109409, 2014

Hwang, S.K., Lu, Y., Li, X., Kim, Y.D., Cho, Y.S., Jahng, Y., Son, J.K., Lee, Y.J., Kang, W., Taketomi, Y., Murakami, M., Moon, T.C., and Chang, H.W.
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
J. Allergy Clin. Immunol., 134, 714-721. e7, 2014

Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
J. Immunol., 192, 1130-1137, 2014

Mishina, H., Tamaru, S., Watanabe, K., Watanabe, Y., Fujioka, D., Takahashi, S., Suzuki, K., Nakamura, T., Obata, J., Kawabata, K., Yokota, Y., Inoue, O., Murakami, M., Hanasaki, K., and Kugiyama, K.
Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
Circ. Res., 114, 493-504, 2014

Udagawa, O., Ito, C., Ogonuki, N., Sato, H., Lee, S., Tripvanuntakul, P., Ichi, I., Uchida, Y., Nishimura, T., Murakami, M., Ogura, A., Inoue, T., Toshimori, K., and Arai, H.
Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
Genes Cells, 19, 13–27, 2014


Review article

Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.
Biochimie., 107, 105-113, 2014

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2013  

Original articles

Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.H., and Murakami, M.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
J. Exp. Med., 210, 1217-1234, 2013

Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nat. Immunol., 14, 554-563, 2013

Tamaru, S, Mishina, H, Watanabe, Y, Watanabe, K, Fujioka, D, Takahashi S, Suzuki, K, Nakamura, T, Obata, JE, Kawabata, K, Yokota, Y, Murakami, M,, Hanasaki, K, and Kugiyama, K.
Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.
J. Immunol., 191,1021-1028, 2013

Morita, Y., Sakaguchi, T., Ikegami, K., Goto-Inoue, N., Hayasaka, T. Hang, V.T., Tanaka, H., Harada, T., Shibasaki, Y., Suzuki, A., Inaba, K., Murakami, M., Setou, M., and Konno, H.
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
J. Hepatol., 59, 292-299, 2013

Miki, T., Kaneda, M., Iida, K., Hasegawa, G., Murakami, M., Yamamoto, N., Asou, H., and Kasahara K.
An anti-sulfatide antibody O4 immunoprecipitates sulfatide rafts including Fyn, Lyn and the G protein α subunit in rat primary immature oligodendrocytes.
Glycoconj. J., 30, 819-823, 2013

Lu, Y., Piao, D., Zhang, H., Li, X., Chao, G.H., Park, S.J., Chang, Y.C., Kim, C.H., Murakami, M., Jung, S.H., Choi, J.H., Son, J.K., and Chang, H.W.
Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcεRI-mediated mast cells.
Food Chem. Toxicol., 59C, 696-702, 2013

Lu, Y., Na, M.K., Suh, S.J., Li, X., Kim, G.J., Chao, G.H., Jeong, Y.T., Kim, D.S., Chang, Y.C., Murakami, M., Kang, W., Kim, C.H., and Chang, H.W.
Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2- dependent prostaglandin D2 generation in mast cells and anaphylaxis in mice.
Food Chem. Toxicol., 57, 307-313, 2013

Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., and Yanoshita, R.
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
Biol. Pharm. Bull., 36, 66-75, 2013.

Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanabe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadawaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, M. J., Arita, M., and Imai, Y.
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Cell, 153, 112-125, 2013

Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T., Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., and Chang, H.W.
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.
J. Allergy Clin. Immunol., 132, 729-736, 2013

Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., and Watanabe, T
The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.
Oncol. Lett., 5, 533-538, 2013

Ait-Oufella, H., Herbin, O., Lahoute, C., Coatrieux, C., Loyer, X., Joffre, J., Laurans, L., Ramkhelawon, B., Blanc-Brude, O., Karabina, S., Girard, C.A., Payré, C., Yamamoto, K., Binder, C. J., Murakami, M., Tedgui, A., Lambeau, G., and Mallat, Z.
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor–null mice
Arterioscler Thromb. Vasc. Biol., 33, 466-473, 2013


Review article

Murakami, M. and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: an update.
Biochimie, 95, 43-50, 2013

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2012  

Original articles

Nakahigashi, K., Otsuka, A., Doi, H., Hirabayashi, T., Murakami, M., Urade, Y., Tanizaki, H., Egawa, G., Miyachi, Y., and Kabashima, K.
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis.
J. Allergy Clin. Immunol., 129, 536-543, 2012

Sasaki, Y., Kamei, D., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Murakami, M., and Hara, S.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Oncogene, 31, 2943-2952, 2012

Lu,Y., Suh, S.J., Li, X., Hwang, S.L., Li, Y., Hwangbo, K., Park, S.J., Murakami, M., Lee, S.H., Jahng, Y., Son, J.K., Kim, C.H., and Chang, H.W.
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Food Chem. Toxicol., 50, 4382-4388, 2012

Lu, Y., Suh, S.J., Li, X., Liang, J.L., Chi, M., Hwangbo, K., Kwon, O., Chung, T.W., Kwak, C.H., Kwon, K.M., Murakami, M., Jahng, Y., Kim, C.H., Son, J.K., and Chang, H.W.
Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-kB and activator protein-1 activation in mouse bone marrow-derived mast cells.
Biol. Pharm. Bull., 35, 938-945, 2012


Review article

Murakami, M. and Taketomi, Y.
Unraveling the secrets of secreated phopholipase A2.
Trends Cell Mol. Biol., 7, 57-71, 2012

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2011  

Original articles

Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., and Murakami, M.
Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts.
J. Biol. Chem., 286, 37249-37263, 2011

Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
J. Biol. Chem., 286, 11616-11631, 2011

Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
J. Biol. Chem., 286, 11632-11648, 2011

Lu , Y., Yang , J.H., Li , X., Hwangbo, K., Hwang , S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., and Chang, H.W.
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Biochem. Pharmacol., 82, 1700-1708, 2011

Miyazaki, T., Taketomi, Y., Takimoto, M.,Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice.
Circulation, 124, 2522-2532, 2011


Review articles

Murakami, M., Taketomi, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Secreted phospholipase A2 revisited.
J. Biochem., 150, 233-255, 2011

Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Resent progress in phospholipase A2 research: From cells to animals to humans.
Prog. Lipid Res., 50, 152-192, 2011

Murakami, M.
Lipid mediators in life science.
Exp. Anim., 60, 7-20, 2011

Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
Integrated lipidomics in the secreted phospholipase A2 biology.
Int. J. Mol. Sci., 12, 1474-1495, 2011

Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., and Murakami, M.
Secreted phospholipase A2, Lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics.
Anal. Bioanal. Chem.,400, 1829-1842, 2011

Taketomi, Y. and Murakami, M.
Phospholipase A2 as a potential target of airway diseases.
Obstructive Airway Diseases: Role of Lipid Mediators, 39-67, 2011

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2010  

Original articles

Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
J. Clin. Invest., 120, 1400-1414, 2010

Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
J. Clin. Invest., 120, 1415-1428, 2010

Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., Kudo, I., and Hara S.
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca2+-indpendent phospholipase A2 (iPLA2 gamma) deficient mice.
J. Lipid Res., 51, 3003-3015, 2010


Review articles

Murakami, M., Taketomi, Y., Girard, C., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.
Biochimie, 92, 561-582, 2010

Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., and Murakami, M.
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
Biochimie, 92, 651-659, 2010

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2009  

Original articles

Kamei, D., Murakami, M., Sasaki, Y., Nakatani, Y., Majima, M., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Hara, S., and Kudo, I.
Microsomal prostaglandin E synthase-1in both cancercells and hosts contributes to tumor growth, invasion and metastasis.
Biochem. J., 425, 361-371, 2009

Ishikawa, Y., Kimura-Matsumoto, M., Murakami, M., Yamamoto, K., Akasaka, Y., Uzuki, M., Yuri, Y., Inomata, N., Yokoo, T. and Ishii, T.
Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis.
J. Atheroscler. Throm., 16, 829-839, 2009

Sato, H., Taketomi, Y., Isogai, Y., Masuda, S., Kobayashi, T., Yamamoto, K., and Murakami, M.
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Biochem. J., 421, 17-27, 2009

Nakamura, Y., Kambe, N., Saito, M., Mishikomori, R., Kim, Y.-G., Murakami, M., Nunez, G., and Matsue, H.
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
J. Exp. Med., 206, 1037-1046, 2009


Review article

Arata, S., Hosono, T., Taketomi, Y., Kageyama, H., Nakamachi, T., and Shioda, S.
Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1R) transgenic mice.
Transmitters and Modulators in Health and Disease, Springer-Verlag, 199-205, 2009

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2008  

Original articles

Sato, H., Kato, R., Isogai, Y., Saka, G., Ohtsuki, M., Taketomi, Y., Yamamoto, K., Tsutsumi, K., Yamada, J., Masuda, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Ikeda, K., Taguchi, R., Hatakeyama, S., Hara, S., Kudo, I., Itabe, H., and Murakami, M.
Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
J. Biol. Chem., 283, 33483-33497, 2008

Ueno, N., Taketomi, Y., Koga, K., Atsumi, Y., Kikuchi-Yanoshita, R., Kudo, I., and Murakami, M.
A negative regulator of delayed prostaglandin D2 production in mouse mast cells.
Biochim. Biophys. Acta, 1781, 415-421, 2008

Masuda, S., Yamamoto, K., Hirabayashi, T., Ishikawa, Y., Ishii, T., Kudo, I., and Murakami, M.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Biochem. J., 409, 429-438, 2008

Yamakawa, K., Kamekura, S., Kawamura, N., Saegusa, M., Kamei, D., Murakami, M., Kudo, I., Uematsu, S., Akira, S., Chung, U.I., Nakamura, K., and Kawaguchi, H.
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis Rheum., 58, 172-183, 2008

Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takamatsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, S.
Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells.
FEBS Lett., 582, 1444-1450, 2008

Kimura-Matsumoto, M., Ishikawa, Y., Komiyama, K., Tsuruta, T., Murakami, M., Masuda, S., Akasaka, Y., Ito, K., Ishiguro, S., Morita, H., Sato, S., and Ishii, T.
Expression of secretory phospholipase A2s in human atherosclerosis development.
Atherosclerosis, 196, 81-91, 2008

Shimizu, M., Nakamura, H., Hirabayashi, T., Suganami, A., Tamura, Y., and Murayama, T.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2 alpha (cPLA2 alpha) by calmodulin-dependent protein kinase: Possible interaction with catalytic domain A of cPLA2 alpha.
Cell Signal., 20, 815-824, 2008

Shimizu, M., Matsumoto, Y., Kurosawa, T., Azuma, C., Enomoto, M., Nakamura, H., Hirabayahsi, T., Kaneko, M., Okuma, Y., and Murayama, T.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase cPLA2 alpha-independent pathway.
Biochem. Pharmacol., 75, 1358-1369, 2008

Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T.
Cytosolic PLA2 alpha activation in purkinje neurons and its role in AMPA-receptor trafficking..
J. Cell Sci., 121, 3015-1024, 2008

Nabemoto, M., Mashimo, M., Someya, A., Nakamura, H., Hirabayashi, T., Fujino, H., Kaneko, M., Okuma, Y., Saito, T., Yamaguchi, N., and Murayama, T.
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A2 alpha .
Eur. J. Parmacol., 590, 1-11, 2008

Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., and Hanada, K.
RalA functions as an indispensable signal mediator for nutrient sensing system.
J. Biol. Chem., 283, 35053-35059, 2008

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2007  

Original articles

Kuwata, H., Fujimoto, C., Yoda, E., Nakatani, Y., Hara, S., Murakami, M., and Kudo, I.
A novel role of group VIB calcium-independent phospholipase A2 (iPLA2 gamma) in the inducible expression of group IIA secretory phospholipase A2 in rat fibroblastic cells.
J. Biol. Chem., 282, 20124-20132, 2007

Taketomi, Y., Sunaga, K., Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T.C., Chang, H.W., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I.
Impaired mast cell maturation and degradation and attenuated allergic responses in Ndrg1-deficient mice.
J. Immunol., 178, 7042-7053, 2007

Miki, Y., Mukae, S., Murakami, M., Ishikawa, Y., Ishii, T., Ohki, H., Matsumoto, M., and Komiyama, K.
Butylate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2.
Anti-Cancer Res., 27, 1493-1502, 2007

Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Vanadate-induced activation of cytosolic phospholipase A2 alpha in L929 cells; roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Biochem. Pharm., 73, 854-862, 2007

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2006  

Original articles

Ohtsuki, M., Taketomi, Y., Arata, S., Masuda, S., Ishikawa, Y., Ishii, T., Takanezawa, Y., Aoki, J., Arai, H., Yamamoto, K., Kudo, I., and Murakami. M.
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
J. Biol. Chem., 281, 36420-36433, 2006

Wijewickrama, G.T., Albanese, A., Kim, Y.J., Oh, Y.S., Murray, P.S., Takayanagi, R., Tobe, T., Masuda, S., Murakami, M., Kudo, I., Ucker, D. S., Murray, D., and Cho, W.
Unique membrane interaction mode of group IIF phospholipase A2.
J. Biol. Chem., 281, 32741-32754, 2006

Mitsuishi, M., Masuda, S., Kudo, I., and Murakami, M.
Group V and X secretory phospholipase A2s prevent adenovirus infection into mammalian cells.
Biochem. J., 393, 97-106, 2006

Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, K., and Maehama, T.
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Mol. Biol. Cell., 17, 4888-4895, 2006

Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., and Murayama, T.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2 alpha.
Eur. J. Pharmacol., 546, 1–10, 2006

Akiyama, N., Nabemoto, M., Hatori, Y., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Up-reguration of cytosolic phospholipase A2 alpha expression by N,N-dimethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.
Toxicol. Appl. Pharmacol., 215, 218–227, 2006

Nakamura, H., Hirabayashi, T., Shimizu, M., and Murayama, T.
Ceramide-1-phosphate activates cytosolic phospholipase A2 alpha directly and by PKC pathway.
Biochem. Pharmacol., 71, 850–857, 2006


Review article

Murakami, M. and Kudo, I.
Prostaglandin E syhthase: a novel drug target for inflammation and cancer.
Curr. Pharm. Des., 12, 943-954, 2006

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2005  

Original articles

Kubota, K., Kubota, K., Kamei, D., Murakami, M., Kudo, I., Aso, I., and Morita, I.
Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.
J. Endocrinol., 187, 339-345, 2005

Ishikawa, Y., Komiyama, I., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima, Y., Kimura, M., Fujimoto, A., Kudo, I., and Ishii, T.
Expression of type V secretory phospholipase A2 in myocardial remodeling after infarction.
Histopathology, 47, 257-267, 2005

Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., and Kudo, I.
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.
Biochem. J., 387, 27-38, 2005

Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.
Biochim. Biophys. Acta, 1736, 200-210, 2005

Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells.
FEBS J., 272, 655-672, 2005

Kuwata, H., Nonaka, T., Murakami, M., and Kudo, I.
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
J. Biol. Chem., 280, 25830-25839, 2005

Murakami, M., Masuda, S., Shimbara, S., Ishikawa, Y., Ishii, T., and Kudo, I.
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A2.
J. Biol. Chem., 280, 24987-24998, 2005

Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., and Kudo, I.
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
J. Biol. Chem., 280, 23203-23214, 2005

Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., and Kudo, I.
Group VIB Ca2+-independent phospholipase A2 (iPLA2 gamma) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s.
J. Biol. Chem., 280, 14028-14041, 2005

Okahara, F., Itoh, K., Ebihara, M., Kobayashi, M., Maruyama, H., Kanaho, Y., and Maehama, T.
Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein.
Anal. Biochem., 336, 138-140, 2005

Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, M. A., Tanaka, K., Penninger, J. M., Yonekawa, H., Suzuki, A., and Kanaho, Y.
Regulation of anaphylactic response by phosphatidylinositol phosphate kinase type Ia.
J. Exp. Med., 201,859-870,2005

Miyazaki, H., Yamazaki, M., Watanabe, H., Maehama, T., Yokozeki, T., and Kanaho, Y.
The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.
FEBS Lett., 579, 6834-6838, 2005


Review articles

Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., and Murakami, M.
Coupling between cyclooxygenasesand terminal prostanoid synthases.
Biochem. Biophys. Res. Commun., 338, 70-76, 2005

Kudo, I. and Murakami, M.
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis..
J. Biochem. Mol. Biol., 38, 633-638, 2005