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原著論文
Hakoi H, Miki Y, Nomura S, Nakajima K, Terashima-Murase C, Takeichi T, Sano S, Akiyama M, Sakasegawa SI, Murakami M, Yamamoto K.
Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2.
Biochimie., 215, 75-87 (2023).
Endo Y, Kanno T, Nakajima T, Ikeda K, Taketomi Y, Yokoyama S, Sasamoto S, Asou HK, Miyako K, Hasegawa Y, Kawashima Y, Ohara O, Murakami M, Nakayama T.
1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in TH17 cells.
Sci. Immunol., 8, eadd4346 (2023).
Nakamura A, Sakai S, Taketomi Y, Tsuyama J, Miki Y, Hara Y, Arai N, Sugiura Y, Kawaji H, Murakami M, Shichita T.
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke.
Neuron., 111, 2995-3010.e9 (2023).
Rahman SMK, Sasaki S, Uyama T, Hussain Z, Sikder MM, Saiga H, Ohmura-Hoshino M, Ohta KI, Miki Y, Hoshino K, Ueno M, Murakami M, Ueda N.
PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice.
FASEB J., 37, e23032 (2023).
Takahama M, Patil A, Johnson K, Cipurko D, Miki Y, Taketomi Y, Carbonetto P, Plaster M, Richey G, Pandey S, Cheronis K, Ueda T, Gruenbaum A, Dudek SM, Stephens M, Murakami M, Chevrier N.
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation.
bioRxiv., 2023.01.30.526342. (2023).
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M. Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami.
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Cell Rep., 42, 111940 (2023).
総説論文
Yamamoto K, Hakoi H, Nomura S, Murakami M.
The Roles of sPLA2s in Skin Homeostasis and Disease.
Biomolecules, 13, 668 (2023).
Murakami M, Sato H, Taketomi Y.
Modulation of immunity by the secreted phospholipase A2 family.
Immunol. Rev., 317, 42-70 (2023).
Harada S, Taketomi Y, Aiba T, Kawaguchi M, Hirabayashi T, Uranbileg B, Kurano M, Yatomi Y, Murakami M.
The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.
Biomolecules., 13, 471 (2023).
Murakami M.
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond.
Pharmacol Ther., 244, 108382 (2023).
原著論文
Takuro Miyazaki, Yoshitaka Taketomi, Takayoshi Higashi, Hirokazu Ohtaki, Takashi Takaki, Koji Ohnishi, Masahiro Hosonuma, Nozomu Kono, Risako Akasu, Shogo Haraguchi, Joo-Ri Kim-Kaneyama, Kinya Otsu, Hiroyuki Arai, Makoto Murakami, Akira Miyazaki.
Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking.
Arterioscler Thromb Vasc Biol., 43, e66-e82 (2022).
Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Keisuke Toda, Saya Maruoka, Yuki Nagasaki, Yoshiko Mori, Risa Sawazumi, Kensuke Okamoto, Keita Kanzaki, Hideyuki Ito, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice.
Free Radic. Biol. Med., 193, 1-8 (2022).
Yuki Nagasaki, Erika Kawai, Saya Maruoka, Miho Osumi, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Yuka Okazaki, Yoshimi Miki, Yoshitaka Taketomi, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects.
Biochem. Biophys. Res. Commun., 630, 84-91 (2022).
S M Khaledur Rahman, Zahir Hussain, Katsuya Morito, Naoko Takahashi, Mohammad Mamun Sikder, Tamotsu Tanaka, Ken-Ichi Ohta, Masaki Ueno, Hiroo Takahashi, Tohru Yamamoto, Makoto Murakami, Toru Uyama, Natsuo Ueda.
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia.
Biochem. Biophys. Acta. Mol. Cell Biol. Lipids., 1867, 159222 (2022).
Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki.
Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.
Sci. Rep., 12, 7312 (2022).
Luyiyun Liang*, Rina Takamiya*, Yoshimi Miki, Kanako Heike, Yoshitaka Taketomi, Nao Sugimoto, Midori Yamaguchi, Hiroshi Shitara, Yasumasa Nishito, Tetsuyuki Kobayashi, Tetsuya Hirabayashi, Makoto Murakami. *Equally contributed.
Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.
FASEB J., 36, e22301 (2022).
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E. Ortiz, Nicholas J. Schnicker, Andrew Thurman, Alejandro A. Pezzulo, Peter J. Szachowicz, Pengfei Li, Ruangang Pan, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, Sonia Zuniga, Isabel Sola, Luis Enjuanes, David K. Meyerholz, Kristen Fortney, Paul B. McCray Jr & Stanley Perlman.
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Nature, 605, 146–151 (2022).
Kai Kudo, Yoshimi Miki, Joaquim Carreras, Shunya Nakayama, Yasushi Nakamoto, Masatoshi Ito, Etsuko Nagashima, Kei Yamamoto, Hiroshi Higuchi, Shin-Ya Morita, Asuka Inoue, Junken Aoki, Kiyoshi Ando, Naoya Nakamura, Makoto Murakami, Ai Kotani.
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma.
Cell Metab., 34, 615-633.e8 (2022).
Etienne Doré, Charles Joly-Beauparlant, Satoshi Morozumi, Alban Mathieu, Tania Lévesque, Isabelle Allaeys, Anne-Claire Duchez, Nathalie Cloutier, Mickaël Leclercq, Antoine Bodein, Christine Payré, Cyril Martin, Agnes Petit-Paitel, Michael H Gelb, Manu Rangachari, Makoto Murakami, Laetitia Davidovic, Nicolas Flamand, Makoto Arita, Gérard Lambeau, Arnaud Droit, Eric Boilard.
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.
JCI Insight, 7, e152638 (2022).
Yoshimi Miki, Yoshitaka Taketomi, Yuh Kidoguchi, Kei Yamamoto, Kazuaki Muramatsu, Yasumasa Nishito, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Tomoyoshi Soga, Eric Boilard, Siddabasave Gowda B. Gowda, Kazutaka Ikeda, Makoto Arita, Makoto Murakami.
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.
JCI Insight, 7: e152611 (2022).
総説論文
Makoto Murakami, Rina Takamiya, Yoshimi Miki, Nao Sugimoto, Yuki Nagasaki, Toshiko Suzuki-Yamamoto, YoshitakaTaketomi.
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation.
Biochem. Pharmacol., 203, 115176 (2022).
Yoshitaka Taketomi, Makoto Murakami.
Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology.
Front. Immunol., 13, 923265 (2022).
Yoshitaka Taketomi, Yoshimi Miki, Makoto Murakami.
Old but new: Group IIA phospholipase A2 as a modulator of gut microbiota.
Metabolites, 12, 352 (2022).
原著論文
Yoshitaka Taketomi, Yuki Endo, Takayoshi Higashi, Remi Murase, Tomio Ono, Choji Taya, Tetsuyuki Kobayashi, Makoto Murakami.
Mast cell-specific deletion of group III secreted phospholipase A2 impairs mast cell maturation and functions.
Cells, 10: 1691 (2021).
Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael H. Gelb, Makoto Murakami, Stanley Perlman.
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
J. Clin. Invest., 131: e147201 (2021).
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Nicholas J Schnicker, Alejandro A Pezzulo, Peter J Szachowicz, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, David K Meyerholz, Kristen Fortney, Paul B McCray, Stanley Perlman.
Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19.
bioRxiv., Preprint (doi: 10.1101/2021.04.20.440676) (2021).
Daisuke Fujioka, Yosuke Watanabe, Takamitsu Nakamura, Takashi Yokoyama, Keiji Miyazawa, Makoto Murakami, Kiyotaka Kugiyama.
Group V secretory phospholipase A2 regulates endocytosis of acetylated LDL by transcriptional activation of PGK1 in RAW264.7 macrophage cell line.
J. Atheroscler. Thromb., 29, 692-718 (2021).
総説論文
Jiro Kitaura, Makoto Murakami.
Positive and negative roles of lipids in mast cells and allergic responses.
Curr. Opin. Immunol., 72: 186-195 (2021).
原著論文
Morishita, M., Kanda, Y., Kaizuka T., Chino, H., Nakao, K., Miki, Y., Taketomi, Y., Jun-Lin Guan, Murakami, M., Aiba, A., Mizushima, N.
Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder.
Cell Reports, 33, 108477, 2020.
Inazumi, T., Yamada, K., Shirata, N., Sato, H., Taketomi, Y., Morita, K., Hohjoh, H., Tsuchiya, S., Oniki, K., Watanabe, T., Sasaki, Y., Oike, Y., Ogata, Y., Saruwatari, J., Murakami, M., Sugimoto, Y.
Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance.
Cell Reports, 33, 108265, 2020
Watanabe, K., Taketomi, Y., Miki, Y., Kugiyama, K., Murakami, M.
Endothelial group V secreted phospholipase A2 plays a protective role against aortic dissection.
J. Biol. Chem., 295, 10092-10111, 2020
Sato, H., Taketomi, Y., Miki, Y., Murase, R., Yamamoto, K., Murakami, M.
Secreted phospholipase PLA2G2D contributes to metabolic health by mobilizing omega-3 polyunsaturated fatty acids in white adipose tissue.
Cell Rep., 31, 107579, 2020
Sano, Y.*, Toyoshima, S.*, Miki, Y.*, Taketomi, Y., Ito, M., Lee, H., Saito, S., Murakami, M., Okayama, Y. *Contributed eaqually.
Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis.
Asia Pac. Allergy, 10, e21, 2020
Toda, K., Tsukayama, I., Nagasaki, Y., Yuka, K., Tamenobu, A., Ganeko, N., Ito, H., Kawakami, Y., Takahashi, Y., Miki, Y., Yamamoto, K., Murakami, M., Suzuki-Yamamoto, T.
Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation.
Arch. Biochem. Biophys., 689, 2020
総説論文
Murakami, M., Sato, H., Taketomi Y.
Updating Phospholipase A2 Biology.
Biomolecules, 10, 1457, 2020
武富 芳隆, 村上 誠
脂質メディエーターとNSAIDs不耐症.
臨床免疫・アレルギー科, 73, 637-643, 2020
原著論文
Mori, A., Hatano, T., Inoshita, T., Shiba-Fukushima, K., Koinuma, T., Meng, H., Kubo, S.I., Spratt, S., Cui, C., Yamashita, C., Miki, Y., Yamamoto, K., Hirabayashi, T., Murakami, M., Takahashi, Y., Shindou, H., Nonaka, T., Hasegawa, M., Okuzumi, A., Imai, Y., Hattori, N.
Parkinson’s disease-assocaitaed iPLA2-VIA/PLA2G6 regulates neuronal functions and a-synuclein stability through membrane remodeling.
Proc. Natl. Acad. Sci. USA., 116, 20689-20699, 2019
Jin, F., Li, X., Deng, Y., Timilshina, M., Huang, B., Kim, D.Y., Chang, J.H., Ichinose, H., Baek, S.H., Murakami, M., Lee, Y.J., Chang, H.W.
The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Allergy, 74, 1145-1156, 2019
総説論文
Murakami, M.
Novel functions of phospholipase A2s: Overview.
Biochim. Biophys. Acta., 1864, 763-765, 2019
Murakami, M., Miki, Y., Sato, H., Murase R, Taketomi, Y., Yamamoto K.
Group IID, IIE, IIF and III secreted phospholipase A2s.
Biochim. Biophys. Acta., 1864, 803-818, 2019
Hirabayashi, T., Murakami, M., Kihara A.
The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function.
Biochim. Biophys. Acta., 1864, 869-879, 2019
武富 芳隆, 村上 誠
ホスホリパーゼA2を起点とした脂質代謝による生命応答の制御.
感染 炎症 免疫, 48 (2), 14-25, 2019
嶋中 雄太, 村上 誠
リピドミクスから見えてきた酸化脂肪酸によるマスト細胞の制御機構.
医学のあゆみ, 270 (5), 401-407, 2019
村上 誠
ホスホリパーゼA2 による代謝と疾患の制御.
医学のあゆみ, 269 (13), 1024-1028, 2019
武富 芳隆, 村上 誠
脂質メディエーターとアレルギー.
実験医学, 37 (10), 88-95, 2019
村上 誠
脂質メディエーターが繋ぐ臓器連関と動的恒常性.
実験医学, 37 (7), 149-155, 2019
佐藤 弘泰, 村上 誠
脂質メディエーターとイムノメタボリズム.
The Lipid, 30 (2), 61-71, 2019
原著論文
Murakami, M., Yamamoto, K., Taketomi, Y.
Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics.
Inflamm. Regen., 38, 31, 2018
Li, X., Park, S.J., Jin, F., Deng, Y., Yang, J.H., Chang, J.H., Kim, D.Y., Kim, J.A., Lee, Y.J., Murakami, M., Son, K.H., Chang, H.W.
Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.
Biochem. Pharmacol., 152, 362-372, 2018
Tsukayama, I., Toda, K., Takeda, Y., Mega, T., Tanaka, M., Kawakami, Y., Takahashi, Y., Kimoto, M., Yamamoto, K., Miki, Y., Murakami, M., and Suzuki-Yamamoto, T.
Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway.
J. Clin. Biochem. Nutr., 62, 139-147, 2018
総説論文
村上 誠
ホスホリパーゼA2群による免疫制御.
臨床免疫・アレルギー科, 70 (3), 193-199, 2018
村上 誠
sPLA2と炎症・免疫.
炎症と免疫, 26 (5), 362-367, 2018
村上 誠
ホスホリパーゼA2ファミリーの多様性と生命応答における役割.
生化学, 90 (3), 348-360, 2018
村上 誠, 武富 芳隆
脂質によるマスト細胞の制御とアレルギー.
医学のあゆみ, 265 (9), 773-778, 2018
村上 誠, 佐藤 弘泰, 武富 芳隆, 平林 哲也
ホスホリパーゼA2ファミリーによるリポクオリティ制御.
実験医学, 36 (10), 1623-1630, 2018
村上 誠, 木原 章雄
脂質による皮膚バリア形成と疾患制御.
実験医学, 36 (10), 1730-1737, 2018
村上 誠
ホスホリパーゼA2と代謝性疾患.
糖尿病学2018, 診断と治療社, 門脇孝編, 56-65, 2018
武富 芳隆, 村上 誠
脂質代謝と喘息.
分子呼吸器病, 22 (1), 18-21, 2018
武富 芳隆, 村上 誠
PLA2とアレルギー.
アレルギー・免疫, 25, 44–53, 2018
武富 芳隆, 村上 誠
分泌性ホスホリパーゼA2と炎症性疾患.
医学のあゆみ, 264 (2), 137-143, 2018
原著論文
Murakami, M.
Lipoquality control by the phospholipase A2 family.
Proc. Jpn. Acad. Ser. B., 93, 677-702, 2017
Shimanaka, Y. & Kono, N., Taketomi, Y., Arita, M., Okayama, Y., Tanaka, Y., Nishito, Y., Mochizuki, T., Kusuhara, H., Adibekian, A., Cravatt, B.F., and Murakami, M. & Arai, H.
ω3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Nat. Med., 23, 1287-1297, 2017
Murase, R., Taketomi, Y., Miki, Y., Nishito, Y., Saito, M., Fukami, K., Yamamoto, K., and Murakami, M.
Group III phospholipase A2 promotes colitis and colorectal cancer.
Sci. Rep., 7, 12261, 2017
Li, X., Lee, Y. J., Jin, F., Park,Y. N., Deng, Y., Kang, Y., Yang, J. H., Chang, J. H., Kim, D. Y., Kim, J. A., Chang, Y. C., Ko, H. J., Kim, C. H., Murakami, M., and Chang, H. W.
Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Sci. Rep., 7, 6444, 2017
Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, T., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J., and Aoki, J.
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
EMBO J., 36, 2146-2160, 2017
Irie, A., Yamamoto, K., Miki, Y., and Murakami, M.
Phosphatidylethanolamine dynamics are required for osteoclast fusion.
Sci. Rep., 7, 46715, 2017
Hirabayashi, T., Anjo, T., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., Muramatsu, K., Fukami, K., Muñoz-Garcia, A., Brash, A.R., Ikeda, K., Arita, M., Akiyama, A., and Murakami, M.
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Nat. Commun., 8, 14609, 2017
総説論文
Murakami, M.
Lipoquality control by phospholipase A2 enzymes.
Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci., 93, 677-702, 2017
村上 誠, 三木 寿美, 山本 圭
リン脂質代謝酵素によるリポクオリティ制御と炎症・免疫.
炎症と免疫, 25, 290-297, 2017
Taketomi, Y., Murakami, M.
Immunological regulation by bioactive lipids.
Yakugaku Zasshi, 137, 503-515, 2017
武富 芳隆, 村上 誠
生理活性脂質による自然免疫・アレルギーの制御.
アレルギーの臨床, 37, 58-62, 2017
平林 哲也, 村上 誠
アシルセラミド生合成と皮膚バリアにおけるPNPLA1の役割.
リポクオリティNewsletter, 2, 34-36, 2017
村上 誠
細胞膜のリン脂質二重膜から局所ホルモンが産み出される仕組み.
生物の科学・遺伝, 71, 163-169, 2017
Yamamoto, K., Miki, Y., Sato, H., Murase, R., Taketomi, Y., and Murakami, M.
Methods Enzymol., 583, 101-117, 2017
原著論文
Hata, S., Kitamura, F., Yamaguchi, M., Shitara, H., Murakami, M., and Sorimachi, H.
A gastrointestinal calpain complex, G-calpain, is a heterodimer of CAPN8 and CAPN9 calpain isoforms, which play catalytic and regulatory roles, respectively.
J. Biol. Chem., 291, 27313-27322, 2016
Tanigawa, H., Miyata, K., Tian, Z., Kadomatsu, T., Aoi, J., Fukushima, S., Ogata, A., Takeda, N., Zhao, J., Zhu, S., Terada, K., Endo, M., Morinaga, J., Sugizaki, T., Sato, M., Morioka, M., Manabe, I., Mashimo, Y., Hata, A., Taketomi, Y., Yamamoto, K., Murakami, M., Araki, K., Jinnin, M., Ihn, H., and Oike, Y.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
Sci. Rep., 6, 34690, 2016
Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J., Murakami, M., Hoka, S., and Yokomizo, T.
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.
Sci. Rep., 6, 34560, 2016
Peña, L., Meana, C., Astudillo, A.M., Lordén, G., Valdearcos, M., Sato, H., Murakami, M., Balsinde, J., and Balboa, M.A.
Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.
Biochim. Biophys. Acta., 1861(9 Pt A), 1083-1095, 2016.
Yamamoto, K., Miki, Y., Sato, H., Nishito, Y., Gelb, M.H., Taketomi, Y., and Murakami, M.
Expression and function of group IIE phospholipase A2 in mouse skin.
J. Biol. Chem., 291, 15602-15613, 2016
Miki, Y., Kidoguchi, Y., Sato, M., Taketomi, Y., Taya, C., Muramatsu, K., Gelb, M.H., Yamamoto, K., and Murakami, M.
Dual roles of group IID phospholipase A2 in inflammation and cancer.
J. Biol. Chem., 291, 15588-15601, 2016
Murase, R., Sato, H., Yamamoto, K., Ushida, A., Nishito, Y., Ikeda, K., Kobayashi, T., Yamamoto, T., Taketomi, Y., and Murakami, M.
Group X secreted phospholipase A2 releases ω-3 polyunsaturated fatty acids, suppresses colitis and promotes sperm fertility.
J. Biol. Chem., 291, 6895-6911, 2016
Li, X., Kwon, O., Kim, D.Y., Taketomi, Y., Murakami, M., and Chang, H.W.
NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module.
Allergy, 71, 198-209, 2016
総説論文
Murakami, M., Yamamoto, K., Miki, Y., Murase, R., Sato, H., and Taketomi, Y.
The roles of the secreted phospholipase A2 (sPLA2) gene family in immunology.
Adv. Immunol., 132, 91-134, 2016
Murakami, M., Taketomi, Y., and Sato, H.
Metabolic regulation by secreted phospholipase A2.
Inflamm. Regener., 36, 1–7, 2016
村上 誠, 原 俊太郎, 中村 元直
エリオット生化学分子生物学第5版, 東京化学同人, 2016 (翻訳監修)
村上 誠
新たな創薬標的の発見を目指した脂質研究の最前線.
バイオサイエンスとインダストリー, 74 (5), 388-395, 2016
武富 芳隆, 村上 誠
肥満細胞と脂質メディエーター.
皮膚アレルギーフロンティア, 14, 19-24, 2016
村上 誠, 三木 寿美, 山本 圭, 武富 芳隆
分泌性ホスホリパーゼA2とアレルギー疾患.
臨床免疫・アレルギー科, 65, 563-568, 2016
佐藤 弘泰、村上 誠
ホスホリパーゼA2と肥満.
糖尿病・代謝・内分泌 Annual Review 2016, 中外医学社, 94-103, 2016
原著論文
Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M.
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J. Exp. Med., 212, 1901–1919, 2015
Vijay, R., Hua, X., Meyerholz, D.K., Miki, Y., Yamamoto, K., Gelb, M.H., Murakami, M., and Perlman, S.
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
J. Exp. Med., 212, 1851-1868, 2015
Gijs, H.L., Willemarck, N., Vanderhoydonc, F., Khan, N. A., Dehairs, J., Derua, R., Waelkens, E., Taketomi, Y., Murakami, M., Agostinis, P., Annaert, W., and Swinnen, J.V.
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Mol. Biol. Cell., 26, 2321-2332, 2015
Kazama, S., Kitayama, J., Hiyoshi, M., Taketomi, Y., Murakami, M., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Kawai, K., Hata, K., Yamaguchi, H., Nozawa, H., Ishihara, S, Sunami, E., and Watanabe, T.
Phospholipase A2 group III and group X have opposing associations with prognosis in colorectal cancer.
Anticancer Res., 35, 2983-2990, 2015
Berry, E., Hernandez-Anzaldo, S., Ghomashchi, F., Lehner, R., Murakami, M., Gelb, M.H., Kassiri, Z., Wang, X., and Fernandez-Patron, C.
Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
J. Am. Heart Assoc., 4, pii: e001868, 2015
Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J. R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
Circ. Res., 116, 1170-1181, 2015
総説論文
Yokomzo, T., and Murakami, M.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 2015 (Editors)
Murakami, M., and Taketomi, Y.
Phospholipase A2.
Bioactive Lipid Mediators: Current Reviews and Protocols, Springer, 23-42, 2015
Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
A new era of secreted phospholipase A2.
J. Lipid Res., 56, 1248-1261, 2015
Murakami, M., and Taketomi, Y.
Secreted phospholipase A2s and mast cells.
Allergology Int., 64, 4-10, 2015
村上 誠
PLA2メタボロームによる疾患脂質代謝マップの創成と生活習慣病解析.
内分泌・糖尿病・代謝内科, 41, 361-369, 2015
武富 芳隆、村上 誠
sPLA2と炎症.
炎症と免疫, 23, 492-498, 2015
村上 誠、横溝 岳彦
実験医学増刊「脂質疾患学：なぜ“あぶら”の異常が病気を引き起こすのか？」, 羊土社, 2015（監修）
久木山 清貴、村上 誠
ホスホリパーゼA2と循環器疾患.
実験医学増刊「脂質疾患学：なぜ“あぶら”の異常が病気を引き起こすのか？」, 羊土社, 33, 2402-2406, 2015
平林 哲也、村上 誠
ホスホリパーゼA2と神経疾患.
実験医学増刊「脂質疾患学：なぜ“あぶら”の異常が病気を引き起こすのか？」, 羊土社, 33, 2456-2461, 2015
村上 誠
ホスホリパーゼA2による代謝シグナル制御.
BioClinica., 30, 33-38, 2015
武富 芳隆、村上 誠
アレルギーと脂質代謝.
臨床免疫・アレルギー科, 62, 659-667, 2015
村上 誠
アレルギーを制御するsPLA2の役割.
細胞, 47, 4-7, 2015
尾池 雄一、佐々木 雄彦、村上 誠、矢作 直也
seriesモデル動物利用マニュアル「疾患モデルの作製と利用：脂質代謝異常と関連疾患（上・下巻）」, エル・アイ・シー, 2015（企画・編集）
平林 哲也、村上 誠
細胞内ホスホリパーゼA2.
seriesモデル動物利用マニュアル「疾患モデルの作製と利用：脂質代謝異常と関連疾患（上・下巻）」 エル・アイ・シー, 147-159, 2015
武富 芳隆、村上 誠
分泌性ホスホリパーゼA2.
seriesモデル動物利用マニュアル「疾患モデルの作製と利用：脂質代謝異常と関連疾患（上・下巻）」, エル・アイ・シー, 160-173, 2015
三木 寿美、山本 圭、村上 誠
接触皮膚炎と抗炎症脂質メディエーター.
臨床免疫・アレルギー科, 63, 156-163, 2015
村上 誠
sPLA2と炎症・免疫.
炎症と免疫, 23, 78-86, 2015
村上 誠
リン脂質からオメガ３脂肪酸を動員するホスホリパーゼA2.
食品と開発, 50, 9-11, 2015
原著論文
Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M.H., and Murakami, M.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Cell Metab., 20, 119-132, 2014
Yoda, E., Rai, K., Ogawa, M., Takakura, Y., Kuwata, H., Suzuki, H., Nakatani, Y., Murakami, M., and Hara, S.
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
PLoS One., 9, e109409, 2014
Hwang, S.K., Lu, Y., Li, X., Kim, Y.D., Cho, Y.S., Jahng, Y., Son, J.K., Lee, Y.J., Kang, W., Taketomi, Y., Murakami, M., Moon, T.C., and Chang, H.W.
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
J. Allergy Clin. Immunol., 134, 714-721. e7, 2014
Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
J. Immunol., 192, 1130-1137, 2014
Mishina, H., Tamaru, S., Watanabe, K., Watanabe, Y., Fujioka, D., Takahashi, S., Suzuki, K., Nakamura, T., Obata, J., Kawabata, K., Yokota, Y., Inoue, O., Murakami, M., Hanasaki, K., and Kugiyama, K.
Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
Circ. Res., 114, 493-504, 2014
Udagawa, O., Ito, C., Ogonuki, N., Sato, H., Lee, S., Tripvanuntakul, P., Ichi, I., Uchida, Y., Nishimura, T., Murakami, M., Ogura, A., Inoue, T., Toshimori, K., and Arai, H.
Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
Genes Cells, 19, 13–27, 2014
総説論文
Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.
Biochimie., 107, 105-113, 2014
武富 芳隆、村上 誠
ホスホリパーゼA2によるマスト細胞の制御.
臨床免疫・アレルギー科, 62, 659-667, 2014
武富 芳隆、村上 誠
リン脂質シグナル、PLA2と発がん.
The Lipids, 25, 70-78, 2014
武富 芳隆
新たなマスト細胞制御因子の同定と制御メカニズムの発見.
YAKUGAKU ZASSHI, 134, 1179–1189, 2014
佐藤 弘泰、村上 誠
リン脂質の質と量の変動が全身の代謝を決める：ホスホリパーゼA2による代謝シグナル.
実験医学増刊—驚愕の代謝システム, 32, 27-33, 2014
武富 芳隆、村上 誠
sPLA2を起点とした脂質ネットワークによる免疫制御の新機軸.
生化学, 86, 286-291, 2014
武富 芳隆、村上 誠
分泌性ホスホリパーゼA2による免疫制御.
医学のあゆみ, 248, 949-955, 2014
原著論文
Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.H., and Murakami, M.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
J. Exp. Med., 210, 1217-1234, 2013
Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nat. Immunol., 14, 554-563, 2013
Tamaru, S, Mishina, H, Watanabe, Y, Watanabe, K, Fujioka, D, Takahashi S, Suzuki, K, Nakamura, T, Obata, JE, Kawabata, K, Yokota, Y, Murakami, M,, Hanasaki, K, and Kugiyama, K.
Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.
J. Immunol., 191,1021-1028, 2013
Morita, Y., Sakaguchi, T., Ikegami, K., Goto-Inoue, N., Hayasaka, T. Hang, V.T., Tanaka, H., Harada, T., Shibasaki, Y., Suzuki, A., Inaba, K., Murakami, M., Setou, M., and Konno, H.
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
J. Hepatol., 59, 292-299, 2013
Miki, T., Kaneda, M., Iida, K., Hasegawa, G., Murakami, M., Yamamoto, N., Asou, H., and Kasahara K.
An anti-sulfatide antibody O4 immunoprecipitates sulfatide rafts including Fyn, Lyn and the G protein α subunit in rat primary immature oligodendrocytes.
Glycoconj. J., 30, 819-823, 2013
Lu, Y., Piao, D., Zhang, H., Li, X., Chao, G.H., Park, S.J., Chang, Y.C., Kim, C.H., Murakami, M., Jung, S.H., Choi, J.H., Son, J.K., and Chang, H.W.
Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcεRI-mediated mast cells.
Food Chem. Toxicol., 59C, 696-702, 2013
Lu, Y., Na, M.K., Suh, S.J., Li, X., Kim, G.J., Chao, G.H., Jeong, Y.T., Kim, D.S., Chang, Y.C., Murakami, M., Kang, W., Kim, C.H., and Chang, H.W.
Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2- dependent prostaglandin D2 generation in mast cells and anaphylaxis in mice.
Food Chem. Toxicol., 57, 307-313, 2013
Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., and Yanoshita, R.
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
Biol. Pharm. Bull., 36, 66-75, 2013.
Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanabe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadawaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, M. J., Arita, M., and Imai, Y.
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Cell, 153, 112-125, 2013
Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T., Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., and Chang, H.W.
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.
J. Allergy Clin. Immunol., 132, 729-736, 2013
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., and Watanabe, T
The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.
Oncol. Lett., 5, 533-538, 2013
Ait-Oufella, H., Herbin, O., Lahoute, C., Coatrieux, C., Loyer, X., Joffre, J., Laurans, L., Ramkhelawon, B., Blanc-Brude, O., Karabina, S., Girard, C.A., Payré, C., Yamamoto, K., Binder, C. J., Murakami, M., Tedgui, A., Lambeau, G., and Mallat, Z.
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor–null mice
Arterioscler Thromb. Vasc. Biol., 33, 466-473, 2013
総説論文
Murakami, M. and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: an update.
Biochimie, 95, 43-50, 2013
村上 誠
分泌性ホスホリパーゼA2による免疫制御.
細胞工学, 12, 1265-127, 2013
武富 芳隆、村上 誠
脂質メディエーターによるアレルギー制御.
実験医学増刊, 31, 118-128, 2013
三木 寿美、山本 圭、村上 誠
疾病における脂質代謝ネットワークの機能.
オレオサイエンス, 13, 10: 485-492, 2013
武富 芳隆、村上 誠
分泌性ホスホリパーゼA2.
The Lipid, 24, 70-78, 2013
武富 芳隆、村上 誠.
脂質ネットワークとアナフィラキシー.
アレルギー・免疫, 20, 8: 38-48, 2013
村上 誠
ホスホリパーゼA2酵素群 最新生理活性脂質研究.
遺伝子医学MOOK, 24, 138-145, 2013（編集）
原著論文
Nakahigashi, K., Otsuka, A., Doi, H., Hirabayashi, T., Murakami, M., Urade, Y., Tanizaki, H., Egawa, G., Miyachi, Y., and Kabashima, K.
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis.
J. Allergy Clin. Immunol., 129, 536-543, 2012
Sasaki, Y., Kamei, D., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Murakami, M., and Hara, S.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Oncogene, 31, 2943-2952, 2012
Lu,Y., Suh, S.J., Li, X., Hwang, S.L., Li, Y., Hwangbo, K., Park, S.J., Murakami, M., Lee, S.H., Jahng, Y., Son, J.K., Kim, C.H., and Chang, H.W.
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Food Chem. Toxicol., 50, 4382-4388, 2012
Lu, Y., Suh, S.J., Li, X., Liang, J.L., Chi, M., Hwangbo, K., Kwon, O., Chung, T.W., Kwak, C.H., Kwon, K.M., Murakami, M., Jahng, Y., Kim, C.H., Son, J.K., and Chang, H.W.
Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-kB and activator protein-1 activation in mouse bone marrow-derived mast cells.
Biol. Pharm. Bull., 35, 938-945, 2012
総説論文
Murakami, M. and Taketomi, Y.
Unraveling the secrets of secreated phopholipase A2.
Trends Cell Mol. Biol., 7, 57-71, 2012
武富 芳隆、村上 誠
PLA2.
動脈硬化症の新しい診断・治療標的, 53-64, 2012
武富 芳隆、村上 誠
アナフィラキシーを制御する脂質ネットワーク.
臨床免疫・アレルギー科, 550-559, 2012
原著論文
Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., and Murakami, M.
Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts.
J. Biol. Chem., 286, 37249-37263, 2011
Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
J. Biol. Chem., 286, 11616-11631, 2011
Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
J. Biol. Chem., 286, 11632-11648, 2011
Lu , Y., Yang , J.H., Li , X., Hwangbo, K., Hwang , S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., and Chang, H.W.
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Biochem. Pharmacol., 82, 1700-1708, 2011
Miyazaki, T., Taketomi, Y., Takimoto, M.,Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice.
Circulation, 124, 2522-2532, 2011
総説論文
Murakami, M., Taketomi, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Secreted phospholipase A2 revisited.
J. Biochem., 150, 233-255, 2011
Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Resent progress in phospholipase A2 research: From cells to animals to humans.
Prog. Lipid Res., 50, 152-192, 2011
Murakami, M.
Lipid mediators in life science.
Exp. Anim., 60, 7-20, 2011
Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
Integrated lipidomics in the secreted phospholipase A2 biology.
Int. J. Mol. Sci., 12, 1474-1495, 2011
Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., and Murakami, M.
Secreted phospholipase A2, Lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics.
Anal. Bioanal. Chem.，400, 1829-1842, 2011
Taketomi, Y. and Murakami, M.
Phospholipase A2 as a potential target of airway diseases.
Obstructive Airway Diseases: Role of Lipid Mediators, 39-67, 2011
武富 芳隆、村上 誠
マスト細胞生物学における脂質代謝ネットワーク.
YAKUGAKU ZASSHI, 131, 73-84, 2011
山本 圭、村上 誠
ホスホリパーゼA2.
生化学, 83, 449-461, 2011
村上 誠
ホスホリパーゼA2・シクロオキシゲナーゼ.
生化学辞典, 2011
佐藤 弘泰、武富 芳隆、山本 圭、村上 誠
高脂血症.
生命科学研究の戦略：疾患モデルマウス表現型解析指南, 278-287, 2011
原著論文
Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
J. Clin. Invest., 120, 1400-1414, 2010
Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
J. Clin. Invest., 120, 1415-1428, 2010
Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., Kudo, I., and Hara S.
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca2+-indpendent phospholipase A2 (iPLA2 gamma) deficient mice.
J. Lipid Res., 51, 3003-3015, 2010
総説論文
Murakami, M., Taketomi, Y., Girard, C., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.
Biochimie, 92, 561-582, 2010
Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., and Murakami, M.
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
Biochimie, 92, 651-659, 2010
村上 誠
脂質メタボロームから見るsPLA2群の生体内機能.
遺伝子医学MOOK, 16, 191-196, 2010
村上 誠
分泌性ホスホリパーゼA2.
日薬理誌, 135, 217-218, 2010
武富 芳隆、村上 誠
分泌性ホスホリパーゼA2遺伝子改変マウス.
The Lipid, 121, 4-12, 2010
村上 誠、佐藤 弘泰、平林 哲也,、山本 圭、武富 芳隆
ホスホリパーゼA2の生理的・病理的役割.
実験医学増刊, 28, 114-125, 2010
原著論文
Kamei, D., Murakami, M., Sasaki, Y., Nakatani, Y., Majima, M., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Hara, S., and Kudo, I.
Microsomal prostaglandin E synthase-1in both cancercells and hosts contributes to tumor growth, invasion and metastasis.
Biochem. J., 425, 361-371, 2009
Ishikawa, Y., Kimura-Matsumoto, M., Murakami, M., Yamamoto, K., Akasaka, Y., Uzuki, M., Yuri, Y., Inomata, N., Yokoo, T. and Ishii, T.
Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis.
J. Atheroscler. Throm., 16, 829-839, 2009
Sato, H., Taketomi, Y., Isogai, Y., Masuda, S., Kobayashi, T., Yamamoto, K., and Murakami, M.
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Biochem. J., 421, 17-27, 2009
Nakamura, Y., Kambe, N., Saito, M., Mishikomori, R., Kim, Y.-G., Murakami, M., Nunez, G., and Matsue, H.
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
J. Exp. Med., 206, 1037-1046, 2009
総説論文
Arata, S., Hosono, T., Taketomi, Y., Kageyama, H., Nakamachi, T., and Shioda, S.
Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1R) transgenic mice.
Transmitters and Modulators in Health and Disease, Springer-Verlag, 199-205, 2009
横溝 岳彦、村上 誠
概論－脂質メディエーターの機能.
実験医学, 27, 2040-2046, 2009
武富 芳隆、佐藤 弘泰、村上 誠
アレルギー性疾患における脂質メディエーターの役割.
実験医学, 27, 2074-2079, 2009
山本 圭、村上 誠
ホスホリパーゼA2と炎症.
炎症と免疫, 17, 359-365, 2009
原著論文
Sato, H., Kato, R., Isogai, Y., Saka, G., Ohtsuki, M., Taketomi, Y., Yamamoto, K., Tsutsumi, K., Yamada, J., Masuda, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Ikeda, K., Taguchi, R., Hatakeyama, S., Hara, S., Kudo, I., Itabe, H., and Murakami, M.
Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
J. Biol. Chem., 283, 33483-33497, 2008.
Ueno, N., Taketomi, Y., Koga, K., Atsumi, Y., Kikuchi-Yanoshita, R., Kudo, I., and Murakami, M.
A negative regulator of delayed prostaglandin D2 production in mouse mast cells.
Biochim. Biophys. Acta, 1781, 415-421, 2008
Masuda, S., Yamamoto, K., Hirabayashi, T., Ishikawa, Y., Ishii, T., Kudo, I., and Murakami, M.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Biochem. J., 409, 429-438, 2008
Yamakawa, K., Kamekura, S., Kawamura, N., Saegusa, M., Kamei, D., Murakami, M., Kudo, I., Uematsu, S., Akira, S., Chung, U.I., Nakamura, K., and Kawaguchi, H.
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis Rheum., 58, 172-183, 2008
Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takamatsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, S.
Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells.
FEBS Lett., 582, 1444-1450, 2008
Kimura-Matsumoto, M., Ishikawa, Y., Komiyama, K., Tsuruta, T., Murakami, M., Masuda, S., Akasaka, Y., Ito, K., Ishiguro, S., Morita, H., Sato, S., and Ishii, T.
Expression of secretory phospholipase A2s in human atherosclerosis development.
Atherosclerosis, 196, 81-91, 2008
Shimizu, M., Nakamura, H., Hirabayashi, T., Suganami, A., Tamura, Y., and Murayama, T.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2 alpha (cPLA2 alpha) by calmodulin-dependent protein kinase: Possible interaction with catalytic domain A of cPLA2 alpha.
Cell Signal., 20, 815-824, 2008
Shimizu, M., Matsumoto, Y., Kurosawa, T., Azuma, C., Enomoto, M., Nakamura, H., Hirabayahsi, T., Kaneko, M., Okuma, Y., and Murayama, T.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase cPLA2 alpha-independent pathway.
Biochem. Pharmacol., 75, 1358-1369, 2008
Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T.
Cytosolic PLA2 alpha activation in purkinje neurons and its role in AMPA-receptor trafficking..
J. Cell Sci., 121, 3015-1024, 2008
Nabemoto, M., Mashimo, M., Someya, A., Nakamura, H., Hirabayashi, T., Fujino, H., Kaneko, M., Okuma, Y., Saito, T., Yamaguchi, N., and Murayama, T.
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A2 alpha .
Eur. J. Parmacol., 590, 1-11, 2008
Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., and Hanada, K.
RalA functions as an indispensable signal mediator for nutrient sensing system.
J. Biol. Chem., 283, 35053-35059, 2008
総説論文
平林 哲也、村上 誠
ホスホリパーゼA2と病態.
BioClinica, 23, 50-55, 2008
村上 誠
sPLA2群の生体内機能とメタボロミクス.
炎症・再生, 28, 454-460, 2008
村上 誠
生化学事典第4版, 一部執筆, 2008
原著論文
Kuwata, H., Fujimoto, C., Yoda, E., Nakatani, Y., Hara, S., Murakami, M., and Kudo, I.
A novel role of group VIB calcium-independent phospholipase A2 (iPLA2 gamma) in the inducible expression of group IIA secretory phospholipase A2 in rat fibroblastic cells.
J. Biol. Chem., 282, 20124-20132, 2007.
Taketomi, Y., Sunaga, K., Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T.C., Chang, H.W., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I.
Impaired mast cell maturation and degradation and attenuated allergic responses in Ndrg1-deficient mice.
J. Immunol., 178, 7042-7053, 2007
Miki, Y., Mukae, S., Murakami, M., Ishikawa, Y., Ishii, T., Ohki, H., Matsumoto, M., and Komiyama, K.
Butylate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2.
Anti-Cancer Res., 27, 1493-1502, 2007
Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Vanadate-induced activation of cytosolic phospholipase A2 alpha in L929 cells; roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Biochem. Pharm., 73, 854-862, 2007
総説論文
村上 誠
脂質の新たな機能を追う.
細胞工学, 11, 2007（監修）
村上 誠
脂質メディエーター研究の現状と展望.
細胞工学, 11, 1218-1220, 2007
山本 圭、平林 哲也、村上 誠
ホスホリパーゼA2の多様性と機能.
細胞工学, 11, 1221-1226, 2007
村上 誠
脂質メタボロームから見た動脈硬化.
BioClinica, 22, 80-85, 2007
村上 誠
メタボリックシンドロームにおける脂質代謝異常と血管障害/ホスホリパーゼA2群の代謝機能を中心に.
血管医学, 8, 17-24, 2007
亀井 大輔、工藤 一郎、村上 誠
COX-2の下流で機能する膜結合型PGE合成酵素（mPGES-1）
治療学, 41, 40-44, 2007
原著論文
Ohtsuki, M., Taketomi, Y., Arata, S., Masuda, S., Ishikawa, Y., Ishii, T., Takanezawa, Y., Aoki, J., Arai, H., Yamamoto, K., Kudo, I., and Murakami. M.
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
J. Biol. Chem., 281, 36420-36433, 2006
Wijewickrama, G.T., Albanese, A., Kim, Y.J., Oh, Y.S., Murray, P.S., Takayanagi, R., Tobe, T., Masuda, S., Murakami, M., Kudo, I., Ucker, D. S., Murray, D., and Cho, W.
Unique membrane interaction mode of group IIF phospholipase A2.
J. Biol. Chem., 281, 32741-32754, 2006
Mitsuishi, M., Masuda, S., Kudo, I., and Murakami, M.
Group V and X secretory phospholipase A2s prevent adenovirus infection into mammalian cells.
Biochem. J., 393, 97-106, 2006
Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, K., and Maehama, T.
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Mol. Biol. Cell., 17, 4888-4895, 2006
Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., and Murayama, T.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2 alpha.
Eur. J. Pharmacol., 546, 1–10, 2006
Akiyama, N., Nabemoto, M., Hatori, Y., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Up-reguration of cytosolic phospholipase A2 alpha expression by N,N-dimethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.
Toxicol. Appl. Pharmacol., 215, 218–227, 2006
Nakamura, H., Hirabayashi, T., Shimizu, M., and Murayama, T.
Ceramide-1-phosphate activates cytosolic phospholipase A2 alpha directly and by PKC pathway.
Biochem. Pharmacol., 71, 850–857, 2006
総説論文
Murakami, M. and Kudo, I.
Prostaglandin E syhthase: a novel drug target for inflammation and cancer.
Curr. Pharm. Des., 12, 943-954, 2006
平林 哲也
肝臓におけるコレステロール合成のフィードバック制御.
ファルマシア, 42, 369-370, 2006
上野 紀子、村上 誠
マスト細胞とアラキドン酸代謝.
アレルギー・免疫, 13, 58-64, 2006
原著論文
Kubota, K., Kubota, K., Kamei, D., Murakami, M., Kudo, I., Aso, I., and Morita, I.
Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.
J. Endocrinol., 187, 339-345, 2005
Ishikawa, Y., Komiyama, I., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima, Y., Kimura, M., Fujimoto, A., Kudo, I., and Ishii, T.
Expression of type V secretory phospholipase A2 in myocardial remodeling after infarction.
Histopathology, 47, 257-267, 2005
Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., and Kudo, I.
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.
Biochem. J., 387, 27-38, 2005
Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.
Biochim. Biophys. Acta, 1736, 200-210, 2005
Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., and Kudo, I.
Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells.
FEBS J., 272, 655-672, 2005
Kuwata, H., Nonaka, T., Murakami, M., and Kudo, I.
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
J. Biol. Chem., 280, 25830-25839, 2005
Murakami, M., Masuda, S., Shimbara, S., Ishikawa, Y., Ishii, T., and Kudo, I.
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A2.
J. Biol. Chem., 280, 24987-24998, 2005
Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., and Kudo, I.
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
J. Biol. Chem., 280, 23203-23214, 2005
Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., and Kudo, I.
Group VIB Ca2+-independent phospholipase A2 (iPLA2 gamma) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s.
J. Biol. Chem., 280, 14028-14041, 2005
Okahara, F., Itoh, K., Ebihara, M., Kobayashi, M., Maruyama, H., Kanaho, Y., and Maehama, T.
Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein.
Anal. Biochem., 336, 138-140, 2005
Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, M. A., Tanaka, K., Penninger, J. M., Yonekawa, H., Suzuki, A., and Kanaho, Y.
Regulation of anaphylactic response by phosphatidylinositol phosphate kinase type Ia.
J. Exp. Med., 201，859-870，2005
Miyazaki, H., Yamazaki, M., Watanabe, H., Maehama, T., Yokozeki, T., and Kanaho, Y.
The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.
FEBS Lett., 579, 6834-6838, 2005
総説論文
Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., and Murakami, M.
Coupling between cyclooxygenasesand terminal prostanoid synthases.
Biochem. Biophys. Res. Commun., 338, 70-76, 2005
Kudo, I. and Murakami, M.
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis..
J. Biochem. Mol. Biol., 38, 633-638, 2005
村上 誠、工藤 一郎
ホスホリパーゼA2研究の展開.
実験医学, 23, 878-885, 2005
上野 紀子、村上 誠
マスト細胞と脂質メディエーター.
アレルギー科, 20, 281-290, 2005
村上 誠、青木 淳賢
脂質シグナリングのフロンティア.
薬事日報, 9856, 11, 2005